Pabon Cindy, Esnakula Ashwini K, Daily Karen
College of Medicine, University of Florida, Gainesville, Florida, USA.
Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, Florida, USA.
BMJ Case Rep. 2018 Dec 19;11(1):e224576. doi: 10.1136/bcr-2018-224576.
A middle-aged woman with a history of leiomyosarcoma of the uterus treated with surgery and adjuvant chemotherapy suffered a bulky metastatic recurrence 1 year later. She elected treatment with palliative eribulin, presenting with acute renal failure and electrolyte abnormalities consistent with tumour lysis syndrome on cycle 1 day 8. Despite aggressive supportive care and treatment including intravenous hydration, bicarbonate and rasburicase, she continued to decline, ultimately foregoing haemodialysis in favour of palliative care and passed away in the hospital.
一名有子宫平滑肌肉瘤病史的中年女性接受了手术及辅助化疗，1年后出现大量转移性复发。她选择接受姑息性艾日布林治疗，在第1周期第8天出现急性肾衰竭及与肿瘤溶解综合征相符的电解质异常。尽管给予了积极的支持治疗，包括静脉补液、碳酸氢盐和重组尿酸氧化酶，但她的病情仍持续恶化，最终放弃血液透析而选择姑息治疗，并在医院去世。
