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诱变和致癌过程中自由基过程的抑制机制。

Mechanisms of inhibition of free-radical processes in mutagenesis and carcinogenesis.

作者信息

Simic M G

机构信息

Center for Radiation Research, National Bureau of Standards, Gaithersburg, MD 20899.

出版信息

Mutat Res. 1988 Dec;202(2):377-86. doi: 10.1016/0027-5107(88)90199-6.

DOI:10.1016/0027-5107(88)90199-6
PMID:3057368
Abstract

Mechanisms of the defense system against genotoxic damage, with emphasis on free-radical processes, are presented. Components of the defense system, interrelationships between components, and the stages in defense are discussed. Examples of free-radical mechanisms of protective agents (mannitol, DMSO) and repair agents (thiols and antioxidants), and the kinetics of their reactions are reviewed. Future trends in the development of novel protective agents are invoked.

摘要

本文介绍了针对基因毒性损伤的防御系统机制，重点是自由基过程。讨论了防御系统的组成部分、各组成部分之间的相互关系以及防御阶段。综述了保护剂（甘露醇、二甲基亚砜）和修复剂（硫醇和抗氧化剂）的自由基机制实例及其反应动力学。还提及了新型保护剂开发的未来趋势。

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Mechanisms of inhibition of free-radical processes in mutagenesis and carcinogenesis.诱变和致癌过程中自由基过程的抑制机制。
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