Dutrillaux B
Ann Genet. 1977 Dec;20(4):221-6.
A theoretical model to explain the occurrence of chromosome rearrangements at the DNA molecular level is proposed. It involves: (10) breakage of one strand of each DNA molecule; (20) enzymatic digestion by an exonuclease of a short sequence of bases adjacent to the lesion, hence the presence of a short monocatenar segment on the complementary strand; (30) association of two monocatenar sequences if they are sufficiently complementary hence the formation of an X-shaped heteroduplex; (40) repair synthesis of DNA and, during this repair, an exhange of strands identical to that occuring in sister-chromatid exchanges, hence the rearrangement. This model has the advantage of necessitating one single breakpoint per DNA molecule, and explains the efficiency of radiations with low linear transfer of energy, such as X- and gamma-rays. It also explains how rearrangements such as translocations can be totally balanced since they would occur base to base within identical sequences.
提出了一个在DNA分子水平解释染色体重排发生的理论模型。它涉及：（10）每个DNA分子的一条链断裂；（20）核酸外切酶对损伤相邻的一小段碱基序列进行酶切消化，因此互补链上存在一小段单链区；（30）如果两个单链序列足够互补则相互结合，从而形成X形异源双链体；（40）DNA的修复合成，并且在这个修复过程中，发生与姐妹染色单体交换中相同的链交换，进而导致重排。该模型的优点是每个DNA分子只需一个单一断点，并且解释了能量线性传递较低的辐射（如X射线和γ射线）的作用效率。它还解释了诸如易位等重排如何能够完全平衡，因为它们会在相同序列内逐个碱基地发生。
