载有 Nutlin 的磁性固体脂质纳米粒用于靶向脑胶质母细胞瘤治疗。
Nutlin-loaded magnetic solid lipid nanoparticles for targeted glioblastoma treatment.
机构信息
Smart Bio-Interfaces, Istituto Italiano di Tecnologia, Viale Rinado Piaggio 34, 56025 Pontedera, Italy.
The Biorobotics Institute, Scuola Superiore Sant'Anna, Viale Rinaldo Piaggio 34, 56025 Pontedera, Italy.
出版信息
Nanomedicine (Lond). 2019 Mar;14(6):727-752. doi: 10.2217/nnm-2018-0436. Epub 2018 Dec 21.
AIM
Glioblastoma multiforme is one of the deadliest forms of cancer, and current treatments are limited to palliative cares. The present study proposes a nanotechnology-based solution able to improve both drug efficacy and its delivery efficiency.
MATERIALS & METHODS: Nutlin-3a and superparamagnetic nanoparticles were encapsulated in solid lipid nanoparticles, and the obtained nanovectors (nutlin-loaded magnetic solid lipid nanoparticle [Nut-Mag-SLNs]) were characterized by analyzing both their physicochemical properties and their effects on U-87 MG glioblastoma cells.
RESULTS
Nut-Mag-SLNs showed good colloidal stability, the ability to cross an in vitro blood-brain barrier model, and a superior pro-apoptotic activity toward glioblastoma cells with respect to the free drug.
CONCLUSION
Nut-Mag-SLNs represent a promising multifunctional nanoplatform for the treatment of glioblastoma multiforme.
目的
多形性胶质母细胞瘤是最致命的癌症之一，目前的治疗方法仅限于姑息治疗。本研究提出了一种基于纳米技术的解决方案，能够提高药物的疗效和递送效率。
材料与方法
将 Nutlin-3a 和超顺磁性纳米颗粒包封在固体脂质纳米粒中，所得纳米载体（载 Nutlin 的磁性固体脂质纳米粒 [Nut-Mag-SLNs]）通过分析其物理化学性质及其对 U-87 MG 神经胶质瘤细胞的影响进行表征。
结果
Nut-Mag-SLNs 表现出良好的胶体稳定性、穿过体外血脑屏障模型的能力以及相对于游离药物对神经胶质瘤细胞更强的促凋亡活性。
结论
Nut-Mag-SLNs 是一种很有前途的多功能纳米平台，可用于治疗多形性胶质母细胞瘤。
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