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[酵母细胞的放射敏感性与辐射传能线密度的关系。二倍体细胞实验]

[Relation of the radiosensitivity of yeast cells to the LET of the radiation. Experiments with diploid cells].

作者信息

Lobachevskiĭ P N, Cherevatenko A P, Mishonova V B

出版信息

Radiobiologiia. 1988 Sep-Oct;28(5):644-52.

PMID:3057534
Abstract

A study was made of the dependence of radiosensitivity D0-1 of diploid yeast cells on linear energy transfer L of radiation, and the obtained results were analyzed in terms of the previously developed model concepts. A diploid-specific repair of radiation damages was shown to be equally effective with different L. This mode of repair had no direct effect on D0-1 (L) function. The observed contribution of the diploid-specific repair to cell radioresistance decreased with increasing L. This, however, was due to physical and geometric factors rather than to the decreased efficiency of diploid-specific repair.

摘要

对二倍体酵母细胞的辐射敏感性D0-1与辐射线能量转移L之间的相关性进行了研究,并根据先前提出的模型概念对所得结果进行了分析。结果表明,不同L值下二倍体特异性辐射损伤修复效果相同。这种修复模式对D0-1(L)函数没有直接影响。观察到二倍体特异性修复对细胞抗辐射性的贡献随L增加而降低。然而,这是由于物理和几何因素,而非二倍体特异性修复效率降低所致。

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