Deroover J, Fryns J P, Parloir C, Van den Berghe H
Ann Genet. 1977 Dec;20(4):263-8.
A large kindred is described in which 22 males and 3 females show non-specific mental retardation with impaired speech. An X-linked recessive is the most likely mode of inheritance of this condition. Similar families have been described in the literature, characteristic physical abnormalities are absent and performance I.Q. tends to be higher than verbal I.Q. This possible heterogenous condition may be a major individual cause of mental deficiency in males, and may account for the excess of male retardates in the population.
本文描述了一个大家族，其中22名男性和3名女性表现出伴有言语障碍的非特异性智力迟钝。X连锁隐性遗传是这种疾病最可能的遗传方式。文献中已描述过类似的家族，其特征是没有明显的身体异常，操作智商往往高于言语智商。这种可能具有异质性的疾病可能是男性智力缺陷的一个主要个体原因，也可能是导致人群中男性智力迟钝者过多的原因。
