Paul R, Dykens E, Leckman J F, Watson M, Breg W R, Cohen D J
Yale Child Study Center.
J Autism Dev Disord. 1987 Dec;17(4):457-68. doi: 10.1007/BF01486963.
Fragile X syndrome is a recently identified form of mental retardation that is associated with a chromosomal abnormality and inherited in an X-linked manner. Previous studies have suggested that distinctive speech and language characteristics are associated with the syndrome. Twelve adult male residents of an institution for the retarded (aged 23 to 51 years) were compared on a series of speech and language measures to 12 adult males with nonspecific forms of MR who were residents of the same institution and were matched on age and IQ. A second contrast group consisted of similarly matched autistic men. Results revealed that there were no significant differences among the groups' performance, with the exception of increased rates of echolalia in the autistic group. A nonsignificant trend toward poorer performance on expressive measures on the part of the fragile X group was noted. The implications of these findings for further research on the syndrome are discussed.
脆性X综合征是一种最近才被确认的智力发育迟缓形式，它与一种染色体异常有关，并以X连锁的方式遗传。先前的研究表明，该综合征与独特的言语和语言特征有关。将一所智障机构中的12名成年男性居民（年龄在23至51岁之间）与同一机构中12名患有非特异性智力发育迟缓的成年男性在一系列言语和语言指标上进行比较，这12名男性在年龄和智商上相匹配。第二个对照组由匹配情况相似的自闭症男性组成。结果显示，除了自闭症组的模仿言语发生率较高外，各组的表现没有显著差异。脆性X组在表达指标上表现较差的趋势不显著。讨论了这些发现对该综合征进一步研究的意义。
