Han Yixin, Corey E J
Department of Chemistry and Chemical Biology , Harvard University , Cambridge , Massachusetts 02138 , United States.
Org Lett. 2019 Jan 4;21(1):283-286. doi: 10.1021/acs.orglett.8b03733. Epub 2018 Dec 21.
A useful catalytic enantioselective approach has been developed for the synthesis of chiral ketamine analogs using Rh(II)-catalyzed amination of triisopropylsilyl enol ethers to form α-amino ketones with O-(4-nitrophenyl)hydroxylamine as nitrogen donor in 81-91% ee.
已开发出一种有用的催化对映选择性方法，用于合成手性氯胺酮类似物，该方法是利用铑（II）催化三异丙基硅基烯醇醚的胺化反应，以O-（4-硝基苯基）羟胺作为氮供体，形成α-氨基酮，对映体过量率为81-91%。
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