印度急性淋巴细胞白血病患儿中MicroRNA 146a的多态性与表达
MicroRNA 146a Polymorphisms and Expression in Indian Children with Acute Lymphoblastic Leukemia.
作者信息
Jemimah Devanandan Helen, Venkatesan Vettriselvi, Scott Julius Xavier, Magatha Latha Sneha, Durairaj Paul Solomon Franklin, Koshy Teena
机构信息
Departments of Human Genetics, Sri Ramachandra Medical College and Research Institute, Porur, Chennai, India.
Departments of Pediatric Medicine, Sri Ramachandra Medical College and Research Institute, Porur, Chennai, India.
出版信息
Lab Med. 2019 Jul 16;50(3):249-253. doi: 10.1093/labmed/lmy074.
BACKGROUND
MicroRNAs (miR) have been reported to be involved in hematopoiesis and in the pathogenesis of several hematological malignant neoplasms. Single-nucleotide polymorphisms (SNPs) in human miR genes may alter the expression of those genes and influence the predisposition to childhood leukemia.
OBJECTIVE
To evaluate the association of rs2910164 G>C, rs57095329 A>G and the expression of miRNA-146a in ethnic South Asian children with acute lymphoblastic leukemia (ALL).
METHOD
Genotyping and expression analysis using TaqMan Small RNA Assay was performed on 71 patients with pathologically confirmed ALL and 74 control individuals.
RESULTS
No statistically significant association was found between the 2 SNPs, its expression levels, and ALL risk.
CONCLUSION
Haplotype analysis indicated a combination of allele A of rs57095329 and allele G of rs2910164 could represent a risk haplotype and an allele combination of G of rs57095329 and G of rs2910164 could represent a protective haplotype for ALL.
背景
据报道，微小RNA（miR）参与造血过程以及几种血液系统恶性肿瘤的发病机制。人类miR基因中的单核苷酸多态性（SNP）可能会改变这些基因的表达，并影响儿童白血病的易感性。
目的
评估南亚裔急性淋巴细胞白血病（ALL）儿童中rs2910164 G>C、rs57095329 A>G与miRNA-146a表达之间的关联。
方法
对71例经病理确诊的ALL患者和74例对照个体进行基因分型，并使用TaqMan小RNA分析进行表达分析。
结果
未发现这两个SNP及其表达水平与ALL风险之间存在统计学上的显著关联。
结论
单倍型分析表明，rs57095329的等位基因A与rs2910164的等位基因G的组合可能代表一种风险单倍型，而rs57095329的等位基因G与rs2910164的等位基因G的组合可能代表ALL的一种保护性单倍型。
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