Association Between the Rs2910164 Polymorphism and Childhood Acute Lymphoblastic Leukemia Susceptibility in an Asian Population.

has been demonstrated to be involved in normal hematopoiesis and the pathogenesis of many hematological malignancies by inhibiting the expression of its targets. Rs2910164(G>C) may modify the expression of the gene, which might influence an individual's predisposition to childhood acute lymphoblastic leukemia (ALL). However, inconsistent findings have been reported on the association between the rs2910164(G>C) polymorphism and the risk of childhood ALL. A comprehensive meta-analysis was performed to accurately estimate the association between the rs2910164 polymorphism and childhood ALL among four different genetic models. This meta-analysis included Asian studies with a total of 1,543 patients and 1,816 controls. We observed a significant difference between patients and controls for the additive model (CC vs. GG: OR = 1.598, 95% CI: 1.003-2.545, = 0.049) using a random effects model. Meanwhile, there was a trend of increased childhood ALL risk in the dominant model (CC + CG vs. GG: OR = 1.501, 95% CI: 0.976-2.307, = 0.065), recessive model (CC vs. GG + CG: OR = 1.142, 95% CI: 0.946-1.380, = 0.168) and allele model (C vs. G: OR = 1.217, 95% CI: 0.987-1.500, = 0.066) between patients and controls. Our findings suggest that the rs2910164 CC genotype was significantly associated with childhood ALL susceptibility.