Department of Food and Nutrition, College of Human Ecology, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Korea.
Research Institute of Human Ecology, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Korea.
Nutrients. 2018 Dec 20;11(1):8. doi: 10.3390/nu11010008.
We aimed to examine whether dietary patterns that explain the variation of triglyceride (TG) to high-density lipoprotein cholesterol (HDL-C) ratio were associated with the incidence of type 2 diabetes in Korean adults. We included a total of 5097 adults without diabetes at baseline with a mean follow-up of 11.54 years. Usual diet was assessed by a validated food frequency questionnaire, and serum levels of TG and HDL-C were measured at baseline. We derived dietary pattern scores using 41 food groups as predictors and the TG/HDL-C ratio as a response variable in a stepwise linear regression. We calculated the odds ratio (OR) with the 95% confidence interval (CI) of type 2 diabetes according to pattern scores using multivariate logistic regression. A total of 1069 incident cases of type 2 diabetes were identified. A list of foods characterizing the dietary pattern differed by sex. Higher dietary pattern scores were associated with an increased risk of type 2 diabetes; ORs (95% CIs) comparing extreme quintiles were 1.53 (1.12⁻2.09; for trend = 0.008) for men and 1.33 (0.95⁻1.86; for trend = 0.011) for women. Our study suggests the evidence that dietary patterns associated with low levels of TG/HDL-C ratio may have the potential to reduce the burden of type 2 diabetes.
我们旨在探讨解释甘油三酯（TG）与高密度脂蛋白胆固醇（HDL-C）比值变化的饮食模式是否与韩国成年人 2 型糖尿病的发病有关。我们共纳入了 5097 名基线时无糖尿病的成年人，平均随访时间为 11.54 年。通过验证后的食物频率问卷评估习惯性饮食，基线时检测 TG 和 HDL-C 的血清水平。我们使用 41 种食物组作为预测因子，以 TG/HDL-C 比值作为响应变量，通过逐步线性回归得出饮食模式得分。我们使用多元逻辑回归根据模式得分计算了 2 型糖尿病的比值比（OR）及其 95%置信区间（CI）。共确定了 1069 例 2 型糖尿病的发病病例。不同性别特征的饮食模式得分存在差异。较高的饮食模式得分与 2 型糖尿病风险增加有关；男性极端五分位数的 OR（95%CI）为 1.53（1.12⁻2.09；趋势检验=0.008），女性为 1.33（0.95⁻1.86；趋势检验=0.011）。我们的研究表明，与 TG/HDL-C 比值低相关的饮食模式可能有潜力降低 2 型糖尿病的负担。
