Zhang Aiwu, Jiang Xiujie, Ge Yunfei, Xu Qingpeng, Li Zhijiang, Tang Huacheng, Cao Dongmei, Zhang Dongjie
College of Food Science, Heilongjiang Bayi Agricultural University, Daqing, China.
National Coarse Cereals Engineering Research Center, Heilongjiang Bayi Agricultural University, Daqing, China.
Front Nutr. 2022 Feb 14;9:849529. doi: 10.3389/fnut.2022.849529. eCollection 2022.
In this study, the effects of γ-aminobutyric acid (GABA)-rich sprouted adzuki beans on the glycolipid metabolism and gastrointestinal health were investigated in mice with type 2 diabetes mellitus (T2DM).
Mice with T2DM were subjected to dietary intervention with different doses of GABA-rich sprouted adzuki beans for 6 consecutive weeks, during which growth indicators, glycolipid metabolism, and the composition and diversity of the gut microbiota changes were observed.
A high dietary intake of GABA-rich sprouted adzuki beans had a preventive effect against weight gain, significantly reduced serum levels of FBG, TG, and TC. Additionally, high dietary intake of GABA-rich sprouted adzuki beans increased the abundances of Firmicutes, Bacteroidetes, Verrucomicrobia, and Akkermansia, leading to a shift in the structure of the gut microbiota toward the dominance of probiotics with regulatory effects on glycolipid metabolism.
GABA-rich sprouted adzuki beans can effectively control the bodyweight of mice with T2DM, maintain a balanced blood glucose level, improve glycolipid metabolism and the changes in the microbiota may mediate the anti-diabetic effect of sprouted adzuki beans.
本研究在2型糖尿病（T2DM）小鼠中，探究富含γ-氨基丁酸（GABA）的发芽赤小豆对糖脂代谢和胃肠道健康的影响。
对T2DM小鼠连续6周进行不同剂量富含GABA的发芽赤小豆饮食干预，在此期间观察生长指标、糖脂代谢以及肠道微生物群组成和多样性的变化。
高剂量摄入富含GABA的发芽赤小豆对体重增加有预防作用，显著降低空腹血糖（FBG）、甘油三酯（TG）和总胆固醇（TC）的血清水平。此外，高剂量摄入富含GABA的发芽赤小豆增加了厚壁菌门、拟杆菌门、疣微菌门和阿克曼氏菌的丰度，导致肠道微生物群结构向对糖脂代谢有调节作用的益生菌优势转变。
富含GABA的发芽赤小豆可有效控制T2DM小鼠的体重，维持血糖水平平衡，改善糖脂代谢，且微生物群的变化可能介导发芽赤小豆的抗糖尿病作用。
