不同粒径和表面涂层的银纳米颗粒对斑马鱼（Danio rerio）不同器官的毒性反应。
Toxicity responses of different organs of zebrafish (Danio rerio) to silver nanoparticles with different particle sizes and surface coatings.
机构信息
MOE Key Laboratory of Resources and Environmental Systems Optimization, College of Environmental Science and Engineering, North China Electric Power University, Beijing, 102206, PR China.
MOE Key Laboratory of Resources and Environmental Systems Optimization, College of Environmental Science and Engineering, North China Electric Power University, Beijing, 102206, PR China.
出版信息
Environ Pollut. 2019 Mar;246:414-422. doi: 10.1016/j.envpol.2018.12.034. Epub 2018 Dec 13.
Silver nanoparticles (AgNPs) in aquatic ecosystems are toxic to aquatic organisms. In this study, we aimed to investigate the toxicities and molecular mechanisms of AgNPs with different surface coatings (sodium citrate and polyvinylpyrrolidone) and particle sizes (20 nm and 100 nm) in the gills, intestines, and muscles of zebrafish after 96 h of exposure. Our results indicated that the contribution of particle size to AgNP toxicity was greater than that of the surface coating. Citrate-coated AgNPs were more toxic than polyvinylpyrrolidone-coated AgNPs, and 20-nm AgNPs were more toxic than 100-nm AgNPs. The toxic effects of AgNPs to the tissues were in the order intestines > gills > muscles. Differential expression of genes with the different AgNPs confirmed that they had toxic effects in the zebrafish tissues at the molecular level. Our comprehensive comparison of the toxicities of different AgNPs to aquatic ecosystems will be helpful for further risk assessments of AgNPs.
在水生生态系统中，银纳米粒子（AgNPs）对水生生物具有毒性。在本研究中，我们旨在研究不同表面涂层（柠檬酸钠和聚乙烯吡咯烷酮）和粒径（20nm 和 100nm）的 AgNPs 在暴露 96 小时后对斑马鱼鳃、肠和肌肉的毒性和分子机制。我们的结果表明，粒径对 AgNP 毒性的贡献大于表面涂层。柠檬酸钠涂层的 AgNPs 比聚乙烯吡咯烷酮涂层的 AgNPs 毒性更大，20nm 的 AgNPs 比 100nm 的 AgNPs 毒性更大。AgNPs 对组织的毒性作用顺序为肠＞鳃＞肌肉。不同 AgNPs 引起的基因差异表达证实了它们在分子水平上对斑马鱼组织具有毒性作用。我们对不同 AgNPs 对水生生态系统毒性的综合比较将有助于进一步评估 AgNPs 的风险。
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