Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam.
Faculty of Chemistry, Graduate University of Science and Technology, VAST, Hanoi, Vietnam.
Nat Prod Res. 2020 Feb;34(3):413-420. doi: 10.1080/14786419.2018.1538219. Epub 2018 Dec 23.
Analysis of an antimicrobial culture broth extract of the sponge-derived actinomycete sp. (strain G246) led to the isolation of two new lavandulylated flavonoids, 6-lavandulyl-7-methoxy-5,2',4'-trihydroxylflavanone () and 5'-lavandulyl-4'-methoxy-2,4,2',6'-tetrahydroxylchalcone (), along with eight known compounds -. Their structures were established by spectral data analysis, including MS, 1D, 2D-NMR and CD. The absolute configurations of and were suggested by comparison of their experimental and calculated electronic circular dichroism spectra. All the isolated compounds were evaluated for their antimicrobial activity against a panel of clinically significant microorganisms. Compounds and had a broad-spectrum of antimicrobial activity. Additionally, except the strain , compound exhibited remarkable inhibitory activity against , , , , , and strains.
分析海绵源放线菌（G246 株）的抗菌发酵液提取物，得到两种新的薰衣草酰化黄酮类化合物，6-薰衣草酰基-7-甲氧基-5,2',4'-三羟基黄酮（）和 5'-薰衣草酰基-4'-甲氧基-2,4,2',6'-四羟基查耳酮（），以及八种已知化合物-。通过光谱数据分析，包括 MS、1D、2D-NMR 和 CD，确定了它们的结构。通过比较实验和计算的电子圆二色谱，推测了和的绝对构型。所有分离得到的化合物均进行了抗临床重要微生物的抗菌活性评价。化合物和具有广谱抗菌活性。此外，除了菌株外，化合物对、、、、、和菌株表现出显著的抑制活性。
