Tajuddeen Nasir, Sallau Muhammad S, Musa Aliyu M, Yahaya Sani M, Habila James D, Ismail Abdullahi Musa
a Department of Chemistry , Ahmadu Bello University Zaria , Zaria 810282 , Nigeria.
b Department of Pharmaceutical and Medicinal Chemistry , Ahmadu Bello University Zaria , Zaria 810282 , Nigeria.
Nat Prod Res. 2016;30(10):1109-15. doi: 10.1080/14786419.2015.1041138. Epub 2015 May 15.
A new flavonoid, 2-(3,5-dihydroxy-4-methoxy-phenyl)-3,5-dihydroxy-8,8-dimethyl-2,3-dihydro-8H-pyrano[3,2]chromen-4-one, together with previously reported epicatechin was isolated from the ethyl acetate soluble fraction of the methanol extract of the stem bark of Commiphora pedunculata. The structures of these compounds were elucidated based on extensive analysis of their spectral data, including 1 and 2D NMR. The compounds were active against 9 out of 12 tested microorganisms including a resistant strain; vancomycin-resistant entrococci (VRE), Escherichia coli, Staphylococcus aureus and Candida albicans. The zones of inhibition ranged between 22 and 34 mm against the microorganisms. The minimum inhibitory concentration was as low as 6.25 μg/mL against Shigella dysentriae, Bacillus cereus and S. aureus while the minimum bactericidal concentration was as low as 50 μg/mL against Pseudomonas aeruginosa, VRE and C. albicans. This is the first report of the isolation of the compound.
从肉豆蔻科没药属植物花梗没药茎皮甲醇提取物的乙酸乙酯可溶部分中，分离出一种新的黄酮类化合物2-(3,5-二羟基-4-甲氧基苯基)-3,5-二羟基-8,8-二甲基-2,3-二氢-8H-吡喃并[3,2]色原酮-4-酮，以及之前报道过的表儿茶素。基于对包括一维和二维核磁共振在内的光谱数据的广泛分析，阐明了这些化合物的结构。这些化合物对12种受试微生物中的9种具有活性，包括一株耐药菌株；耐万古霉素肠球菌（VRE）、大肠杆菌、金黄色葡萄球菌和白色念珠菌。对这些微生物的抑菌圈范围在22至34毫米之间。对痢疾志贺菌、蜡样芽孢杆菌和金黄色葡萄球菌的最低抑菌浓度低至6.25μg/mL，而对铜绿假单胞菌、VRE和白色念珠菌的最低杀菌浓度低至50μg/mL。这是该化合物分离的首次报道。
