Barth J D, Blankenhorn D H, Wickham E, Lai J Y, Chin H P, Selzer R H
Biomedical Image Processing Laboratory, California Institute of Technology, Pasadena.
Arteriosclerosis. 1988 Nov-Dec;8(6):778-81. doi: 10.1161/01.atv.8.6.778.
Pulsation in the human carotid artery during two complete cardiac cycles was studied by using computer digitized video-frames from B-mode ultrasound images. Eight patients with identifiable atherosclerotic lesions in the common carotid immediately proximal to the bulb area were studied. Diameter, strain, and elastic modulus were compared between lesion site and an adjacent reference segment 1 or 2 cm proximal to the bulb. As controls, nine patients without identifiable lesions were analyzed. The results indicate a significantly wider diameter (p less than 0.01) at the proximal reference site in patients with lesions as compared to comparable segments in control patients. The strain was significantly lower (p less than 0.05), whereas the elastic modulus was significantly higher (p less than 0.05), at the lesion site as compared to the proximal reference sites in patients with lesions. These results may indicate that an initial dilation of the carotid artery followed by loss of wall flexibility may be associated with atherosclerotic lesion formation.
利用B型超声图像的计算机数字化视频帧，对两个完整心动周期内人体颈动脉的搏动情况进行了研究。研究对象为8例在球部区域近端的颈总动脉有可识别动脉粥样硬化病变的患者。比较了病变部位与球部近端1或2厘米处相邻参考节段的直径、应变和弹性模量。作为对照，分析了9例无明显病变的患者。结果表明，与对照患者的可比节段相比，有病变患者近端参考部位的直径明显更宽（p<0.01）。与有病变患者的近端参考部位相比，病变部位的应变明显更低（p<0.05），而弹性模量明显更高（p<0.05）。这些结果可能表明，颈动脉的初始扩张随后伴有管壁柔韧性丧失，可能与动脉粥样硬化病变形成有关。
