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眼睑神经鞘瘤病例报告:儿童中的罕见表现。

Case report of eyelid schwannoma: A rare presentation in a child.

作者信息

Ittarat Mantapond, Srihachai Pakamat, Chansangpetch Sunee

机构信息

Department of Ophthalmology, Prasat Hospital, Surin, Thailand.

Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Bangkok, Thailand.

出版信息

Am J Ophthalmol Case Rep. 2018 Dec 5;13:56-58. doi: 10.1016/j.ajoc.2018.12.005. eCollection 2019 Mar.

Abstract

PURPOSE

To report a rare case of solitary eyelid schwannoma in a Thai child without clinical manifestation of neurofibromatosis.

OBSERVATIONS

A 9-year-old Thai boy presented with an isolated painless mass on the left lower eyelid. The mass had gradually grown for 2 years. He denied a history of trauma or previous eyelid surgery. A clinical examination revealed no clinical features of neurofibromatosis. The provisional diagnosis at that time was a sebaceous cyst. However, excisional biopsy showed an encapsulated tumor characterized by interlaced spindle-celled fasciculi with focal palisading of nuclei arranging in Antoni A and Antoni B patterns. The immunocytochemistry was strongly positive for S-100 protein reaction. The diagnosis of schwannoma was made, with no recurrence at.

CONCLUSIONS AND IMPORTANCE

Schwannoma of the eyelid is extremely rare in children, accounting for less than 0.1% of all eyelid tumors. Combined with clinical features, histopathologic and immunohistochemical analyses emphasize the disease entities. These findings may extend the knowledge on experiences of schwannoma in children.

摘要

目的

报告1例泰国儿童孤立性眼睑神经鞘瘤,该患儿无神经纤维瘤病的临床表现。

观察结果

一名9岁泰国男孩左下眼睑出现一个孤立的无痛性肿块。该肿块已逐渐增大2年。他否认有外伤史或既往眼睑手术史。临床检查未发现神经纤维瘤病的临床特征。当时的初步诊断为皮脂腺囊肿。然而,切除活检显示为一个包膜肿瘤,其特征为交织的梭形细胞束,细胞核局灶性栅栏状排列,呈Antoni A和Antoni B模式。免疫细胞化学检测S-100蛋白反应呈强阳性。诊断为神经鞘瘤,随访无复发。

结论与意义

眼睑神经鞘瘤在儿童中极为罕见,占所有眼睑肿瘤的比例不到0.1%。结合临床特征、组织病理学和免疫组化分析可明确疾病类型。这些发现可能会扩展对儿童神经鞘瘤经验的认识。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7df6/6288314/8016c6e13426/gr1.jpg

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