Ittarat Mantapond, Srihachai Pakamat, Chansangpetch Sunee
Department of Ophthalmology, Prasat Hospital, Surin, Thailand.
Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Bangkok, Thailand.
Am J Ophthalmol Case Rep. 2018 Dec 5;13:56-58. doi: 10.1016/j.ajoc.2018.12.005. eCollection 2019 Mar.
To report a rare case of solitary eyelid schwannoma in a Thai child without clinical manifestation of neurofibromatosis.
A 9-year-old Thai boy presented with an isolated painless mass on the left lower eyelid. The mass had gradually grown for 2 years. He denied a history of trauma or previous eyelid surgery. A clinical examination revealed no clinical features of neurofibromatosis. The provisional diagnosis at that time was a sebaceous cyst. However, excisional biopsy showed an encapsulated tumor characterized by interlaced spindle-celled fasciculi with focal palisading of nuclei arranging in Antoni A and Antoni B patterns. The immunocytochemistry was strongly positive for S-100 protein reaction. The diagnosis of schwannoma was made, with no recurrence at.
Schwannoma of the eyelid is extremely rare in children, accounting for less than 0.1% of all eyelid tumors. Combined with clinical features, histopathologic and immunohistochemical analyses emphasize the disease entities. These findings may extend the knowledge on experiences of schwannoma in children.
报告1例泰国儿童孤立性眼睑神经鞘瘤,该患儿无神经纤维瘤病的临床表现。
一名9岁泰国男孩左下眼睑出现一个孤立的无痛性肿块。该肿块已逐渐增大2年。他否认有外伤史或既往眼睑手术史。临床检查未发现神经纤维瘤病的临床特征。当时的初步诊断为皮脂腺囊肿。然而,切除活检显示为一个包膜肿瘤,其特征为交织的梭形细胞束,细胞核局灶性栅栏状排列,呈Antoni A和Antoni B模式。免疫细胞化学检测S-100蛋白反应呈强阳性。诊断为神经鞘瘤,随访无复发。
眼睑神经鞘瘤在儿童中极为罕见,占所有眼睑肿瘤的比例不到0.1%。结合临床特征、组织病理学和免疫组化分析可明确疾病类型。这些发现可能会扩展对儿童神经鞘瘤经验的认识。