根据不同临床表现的贝赫切特病患者的血清免疫球蛋白 D 水平。

Serum immunoglobulin D levels in patients with Behçet's disease according to different clinical manifestations.

机构信息

Research Centre of Systemic Autoinflammatory Diseases, Behçet's Disease Clinic and Rheumatology-Ophthalmology Collaborative Uveitis Centre, Department of Medical Sciences, Surgery and Neurosciences, University of Siena, Italy.

Department of Ophthalmology, Humanitas Clinical and Research Centre, Rozzano, and Ophthalmology Unit, Department of Medicine, Surgery and Neuroscience, University of Siena, Italy.

出版信息

Clin Exp Rheumatol. 2018 Nov-Dec;36(6 Suppl 115):110-115. Epub 2018 Dec 12.

PMID:30582507

Abstract

OBJECTIVES

Behçet's disease (BD) is an autoinflammatory disorders mainly characterised by recurrent oral aphthosis, genital ulcers, and uveitis. The involvement of immunoglobulin D (IgD) in BD physiopathology is still unclear. The aim of our study was to assess the role of IgD in BD by comparing circulating levels of IgD in a cohort of BD patients and healthy controls (HC), as well as by correlating IgD levels with BD activity and different clinical presentations.

METHODS

Serum IgD and SAA levels were analysed by ELISA assay in ninety-nine serum samples collected from 72 BD patients and in 29 HC subjects.

RESULTS

Serum concentration of IgD were higher in BD patients compared with HC (p=0.029), in patients with high serum amyloid A (SAA) levels compared with patients with normal SAA levels (p=0.035), and among subjects with active mucocutaneous involvement compared with other patients (p=0.036). No correlations were identified between IgD serum levels and disease activity assessed by the BD current activity form (BDCAF) (p=0.640). No differences were observed in the IgD serum levels between patients with and without specific disease manifestations. Increased SAA levels (Odds Ratio = 3.978, CI: 1.356 -11.676) and active mucocutaneous BD manifestations (Odds Ratio = 4.286, CI: 1.192 - 15.407) were associated with a high risk for increased IgD serum levels.

CONCLUSIONS

Serum IgD levels are significantly increased in BD patients, especially among patients with active mucocutaneous manifestations, suggesting a possible role of IgD in BD pathogenesis and in the onset of mucosal and skin lesions.

摘要

目的

贝赫切特病（BD）是一种主要以复发性口腔溃疡、生殖器溃疡和葡萄膜炎为特征的自身炎症性疾病。免疫球蛋白 D（IgD）在 BD 病理生理学中的作用尚不清楚。本研究旨在通过比较 BD 患者和健康对照者（HC）的循环 IgD 水平，以及将 IgD 水平与 BD 活动度和不同临床表现相关联，来评估 IgD 在 BD 中的作用。

方法

通过 ELISA 法分析了 72 例 BD 患者和 29 例 HC 受试者的 99 份血清样本中的血清 IgD 和 SAA 水平。

结果

与 HC 相比，BD 患者的血清 IgD 浓度更高（p=0.029），与 SAA 水平正常的患者相比，SAA 水平升高的患者（p=0.035），以及与其他患者相比，黏膜皮肤活动受累的患者（p=0.036）。BD 当前活动表（BDCAF）评估的疾病活动与 IgD 血清水平之间未发现相关性（p=0.640）。在有无特定疾病表现的患者之间，血清 IgD 水平没有差异。升高的 SAA 水平（优势比=3.978，CI：1.356-11.676）和活跃的黏膜皮肤 BD 表现（优势比=4.286，CI：1.192-15.407）与 IgD 血清水平升高的高风险相关。