空腹血糖变异性水平与 2 型糖尿病患者不良结局风险的关系：系统评价和荟萃分析。
Fasting plasma glucose variability levels and risk of adverse outcomes among patients with type 2 diabetes: A systematic review and meta-analysis.
机构信息
The Graduate School, Xuzhou Medical University, Xuzhou, Jiangsu 221002, PR China.
Laboratory of Morphology, Xuzhou Medical University, Xuzhou, Jiangsu 221004, PR China.
出版信息
Diabetes Res Clin Pract. 2019 Feb;148:23-31. doi: 10.1016/j.diabres.2018.12.010. Epub 2018 Dec 21.
AIM
This systematic review and meta-analysis assessed the association between fasting plasma glucose (FPG) variability levels and the risk of retinopathy and all-cause mortality in patients with type 2 diabetes.
METHODS
PubMed and EMBASE were searched to identify studies that evaluated the association between FPG variability and retinopathy and all-cause mortality in patients with type 2 diabetes mellitus. The hazard ratios (HRs) and 95% confidence intervals (CIs) were pooled with the random-effects model.
RESULTS
Eight studies were included in our meta-analysis. Five studies evaluated the impact of FPG variability on all-cause mortality and showed that high FPG variability was associated with the risk of all-cause mortality (HR 1.28, 95% CI 1.12-1.46; three studies). For median or mean FPG variability levels under 20%, the relationship between all-cause mortality and FPG variability was not significant. Three studies evaluated FPG variability and the risk of diabetic retinopathy and showed that high FPG variability was strongly associated with the risk of retinopathy (odds ratio (OR) = 3.68; 95% CI 1.01-13.4).
CONCLUSION
High FPG variability levels were positively associated with the risk of retinopathy and all-cause mortality in patients with type 2 diabetes.
目的
本系统评价和荟萃分析评估了空腹血糖（FPG）变异性水平与 2 型糖尿病患者视网膜病变和全因死亡率风险之间的关系。
方法
检索 PubMed 和 EMBASE，以确定评估 2 型糖尿病患者 FPG 变异性与视网膜病变和全因死亡率之间关系的研究。使用随机效应模型汇总风险比（HR）和 95%置信区间（CI）。
结果
本荟萃分析纳入了 8 项研究。有 5 项研究评估了 FPG 变异性对全因死亡率的影响，结果表明高 FPG 变异性与全因死亡率风险相关（HR 1.28，95%CI 1.12-1.46；有 3 项研究）。对于中位数或平均值 FPG 变异性水平低于 20%，全因死亡率与 FPG 变异性之间的关系不显著。有 3 项研究评估了 FPG 变异性与糖尿病视网膜病变的风险，结果表明高 FPG 变异性与视网膜病变风险密切相关（比值比（OR）=3.68；95%CI 1.01-13.4）。
结论
高 FPG 变异性水平与 2 型糖尿病患者的视网膜病变和全因死亡率风险呈正相关。
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