Chai Yi, Chen Chengyu, Yin Xueru, Wang Xinru, Yu Wenyan, Pan Haochen, Qin Ruiying, Yang Xiyue, Wang Qiuzhen
School of Public Health, Qingdao University, Qingdao, China.
School of Public Health, Qingdao University, Qingdao, China. Email:
Asia Pac J Clin Nutr. 2025 Feb;34(1):118-130. doi: 10.6133/apjcn.202502_34(1).0012.
Growing evidence has explored the effects of water-soluble vitamins supplementation on glycemic control and insulin resistance in diabetic patients; however, the results of previous meta-analyses are inconsistent. To address this, we conducted an umbrella review to synthesize the evidence on these effects.
A systematic literature search in Web of science, PubMed, and Cochrane Database of Systematic Reviews was performed from 2012 to November 2022. he quality of the meta-analyses was assessed using AMSTAR-2 and GRADE.
Fourteen systematic reviews and meta-analyses met the inclusion criteria, examining the effects of five water-soluble vitamins (B-1, B-3, biotin, B-9, and C) on glycemic control and insulin resistance. The findings suggest that vitamin C supplementation can improve glycemic control in type 2 diabetes, as indicated by reduced FBG and HbA1c, with more significant effects observed for durations longer than 30 days.
Insulin resistance is improved by folic acid supplementations. More well-designed individual randomized controlled trials are needed in the future, as well as meta-analysis of higher quality.
越来越多的证据探讨了补充水溶性维生素对糖尿病患者血糖控制和胰岛素抵抗的影响；然而，以往荟萃分析的结果并不一致。为解决这一问题，我们进行了一项综合评价以综合这些影响的证据。
于2012年至2022年11月在科学网、PubMed和Cochrane系统评价数据库中进行了系统的文献检索。使用AMSTAR-2和GRADE评估荟萃分析的质量。
14项系统评价和荟萃分析符合纳入标准，研究了5种水溶性维生素（维生素B-1、B-3、生物素、B-9和C）对血糖控制和胰岛素抵抗的影响。研究结果表明，补充维生素C可改善2型糖尿病患者的血糖控制，空腹血糖（FBG）和糖化血红蛋白（HbA1c）降低表明了这一点，在超过30天的疗程中观察到更显著的效果。
补充叶酸可改善胰岛素抵抗。未来需要更多设计良好的个体随机对照试验以及更高质量的荟萃分析。
