State Key Laboratory of Pig Genetic Improvement and Production Technology, Jiangxi Agricultural University, 330045, Nanchang, China.
State Key Laboratory of Pig Genetic Improvement and Production Technology, Jiangxi Agricultural University, 330045, Nanchang, China.
Meat Sci. 2019 Apr;150:47-55. doi: 10.1016/j.meatsci.2018.12.008. Epub 2018 Dec 18.
This study investigated genetic correlations of longissimus muscle fatty acid composition with 32 traits related to growth, carcass, fat deposition and meat quality in 2448 pigs from six populations using genome wide SNP data. Most of significant loci for saturated (C14:0, C16:0 and C18:0) and mono-saturated fatty acids (C18:1n9 and C16:1n7) identified in GWAS, including those near ELOVL6, SCD and FASN genes, displayed negligible or weak effects on all the 32 traits. Fat deposition traits were the most relevant traits for fatty acid composition in genetic correlations. Backfat thickness and intramuscular fat content consistently showed strong negative genetic correlations with C18:2n6, and positive genetic correlations with C18:1n9 at least five populations. Intramuscular fat content consistently has positive correlations with saturated fatty acids (SFA) in six populations. This study provided insights into shared genetic control of fatty acid composition and the other economic traits, which is helpful in design of breeding strategies to genetically improve fatty acid composition in pork.
本研究利用全基因组 SNP 数据，在六个群体的 2448 头猪中，调查了背最长肌脂肪酸组成与生长、胴体、脂肪沉积和肉质相关的 32 个性状的遗传相关性。在 GWAS 中鉴定的大多数显著的饱和脂肪酸（C14:0、C16:0 和 C18:0）和单不饱和脂肪酸（C18:1n9 和 C16:1n7）的位点，包括靠近 ELOVL6、SCD 和 FASN 基因的那些位点，对所有 32 个性状的影响都可以忽略不计或较弱。脂肪沉积性状与遗传相关性中的脂肪酸组成最相关。在至少五个群体中，背膘厚和肌内脂肪含量与 C18:2n6 呈显著负遗传相关，与 C18:1n9 呈显著正遗传相关。在六个群体中，肌内脂肪含量与饱和脂肪酸（SFA）始终呈正相关。本研究深入了解了脂肪酸组成和其他经济性状的共同遗传控制，有助于设计育种策略，从遗传上改善猪肉的脂肪酸组成。
