Sarfeh I J, Tarnawski A, Stachura J, Hajduczek A, Bui H X
Department of Surgery, Long Beach VA Medical Center, CA 90822.
Folia Histochem Cytobiol. 1988;26(3):119-22.
We studied histochemical and ultrastructural characteristics of the gastric submucosal blood vessels in portal hypertensive (PHT) rats. PHT was induced by two-stage ligation of the portal vein. Control rats were sham operated (SO). On the fifth day after surgery portal vein blood pressure was measured and rats were killed under nembutal anesthaesia. Gastric specimens were obtained for histological, histochemical and ultrastructural assessment. PHT rats showed thickening and increased cellularity of submucosal vessels including increase in number and size of endothelial cells. All these mesenchymal cells were vimentin-positive. Thickening of vascular wall in submucosal vessels was also observed ultrastructurally together with prominent elaboration of luminal surface of endothelial cells. These changes were not observed in SO rats. All changes in PHT rats reflect vasculopathic involvement of gastric wall in portal hypertension.
我们研究了门静脉高压（PHT）大鼠胃黏膜下血管的组织化学和超微结构特征。通过门静脉两阶段结扎诱导PHT。对照大鼠接受假手术（SO）。术后第5天测量门静脉血压，并在戊巴比妥麻醉下处死大鼠。获取胃标本进行组织学、组织化学和超微结构评估。PHT大鼠显示黏膜下血管增厚且细胞增多，包括内皮细胞数量和大小增加。所有这些间充质细胞波形蛋白呈阳性。超微结构还观察到黏膜下血管壁增厚以及内皮细胞腔面显著增生。SO大鼠未观察到这些变化。PHT大鼠的所有变化反映了门静脉高压时胃壁的血管病变累及。
