肽化学中的逆电子需求狄尔斯-阿尔德（IEDDA）反应。
Inverse electron demand Diels-Alder (IEDDA) reactions in peptide chemistry.
作者信息
Pagel Mareen
机构信息
Institute of Biochemistry, Faculty of Biosciences, Pharmacy and Psychology, Leipzig University, Leipzig, Germany.
出版信息
J Pept Sci. 2019 Jan;25(1):e3141. doi: 10.1002/psc.3141.
DOI:10.1002/psc.3141
PMID:30585397
Abstract
Click chemistry is applied to selectively modify, lable and ligate peptides for their use as therapeutics, in biomaterials or analytical investigations. The inverse electron demand Diels-Alder (IEDDA) reaction is a catalyst-free click reaction with pronounced chemoselectivity and fast reaction rates. Applications and achievements of the IEDDA reaction in peptide chemistry since 2008 are described in this review.
摘要
点击化学被应用于对肽进行选择性修饰、标记和连接，以用于治疗、生物材料或分析研究。逆电子需求狄尔斯-阿尔德（IEDDA）反应是一种无催化剂的点击反应，具有显著的化学选择性和快速的反应速率。本文综述了自2008年以来IEDDA反应在肽化学中的应用和成果。
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