抗蛋白酶抑肽酶对外周血白细胞的影响。
Effects of the antiprotease Trasylol on peripheral blood leucocytes.
作者信息
Thomson A W, Pugh-Humphreys R G, Tweedie D J, Horne C H
出版信息
Experientia. 1978 Apr 15;34(4):528-30. doi: 10.1007/BF01935971.
PMID:305854
Abstract
Binding of the antiprotease Trasylol to human peripheral blood lymphocytes and polymorphonuclear leucocytes (PMNs) was demonstrated at the ultrastructural level using an indirect immunoperoxidase technique. This also revealed endocytosis of membrane bound Trasylol by PMNs. Trasylol inhibited PHA- and ConA-induced lymphocyte stimulation, and was cytotoxic to unstimulated cells.
摘要
使用间接免疫过氧化物酶技术在超微结构水平上证实了抗蛋白酶抑肽与人类外周血淋巴细胞和多形核白细胞（PMN）的结合。这也揭示了PMN对膜结合抑肽的内吞作用。抑肽抑制了PHA和ConA诱导的淋巴细胞刺激，并且对未刺激的细胞具有细胞毒性。
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