大肠杆菌染色体的分子进化。II. 克隆区段。
Molecular evolution of the Escherichia coli chromosome. II. Clonal segments.
作者信息
Milkman R, Stoltzfus A
机构信息
Department of Biology, University of Iowa, Iowa City 52242.
出版信息
Genetics. 1988 Oct;120(2):359-66. doi: 10.1093/genetics/120.2.359.
Abstract
Remarkable sequence similarities in the trp region among Escherichia coli strains of diverse natural origins imply the existence of worldwide clones of very recent origin. This in turn implies a low rate of fixation of new universally favorable alleles, which carry adjacent stretches of chromosome to high frequency. These clonal segments begin as entire chromosomes; recombination shortens them progressively by substituting less closely related homologous DNA. The rate of this recombination, comprising the introduction of a homologous chromosomal fragment to a cell and the replacement of part of the original chromosome, is estimated from observations.
摘要
不同自然来源的大肠杆菌菌株在色氨酸区域存在显著的序列相似性，这意味着存在起源非常近的全球克隆。这反过来又意味着新的普遍有利等位基因的固定率较低，这些等位基因会将相邻的染色体片段带到高频。这些克隆片段最初是完整的染色体；重组通过替换关系不太密切的同源DNA逐渐缩短它们。这种重组的速率，包括将同源染色体片段引入细胞以及替换部分原始染色体，是通过观察估计的。
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