Emami-Naeini Parisa, Yiu Glenn
Int Ophthalmol Clin. 2019 Winter;59(1):195-207. doi: 10.1097/IIO.0000000000000251.
In recent years, advances in ocular imaging, drug delivery, and ophthalmic surgery have allowed for better visualization and access to the suprachoroidal space. Although previously considered as only a potential space, the suprachoroidal space may serve as a route for drug delivery to the posterior pole, an egress for glaucoma drainage devices, a location for temporary buckling, and a site for prosthesis implantation. Drugs delivered to the suprachoroidal space may achieve higher concentrations in the retina while minimizing exposure to anterior segment tissues, potentially reducing risks of glaucoma or cataracts. Finally, advanced multimodal imaging now allows not only a better understanding of the physiology of the suprachoroid, but also in vivo monitoring of pathologies and drug delivery to the suprachoroidal space. Here, we discuss the newest developments in the medical and surgical applications of this space with potential.
近年来,眼部成像、药物递送和眼科手术的进展使得对脉络膜上腔有了更好的可视化和进入途径。尽管脉络膜上腔以前仅被视为一个潜在空间,但它可能成为药物递送至后极部的途径、青光眼引流装置的出口、临时巩膜扣带的位置以及假体植入的部位。递送至脉络膜上腔的药物可在视网膜中达到更高浓度,同时尽量减少眼前节组织的暴露,从而有可能降低青光眼或白内障的风险。最后,先进的多模态成像现在不仅能更好地了解脉络膜上腔的生理学,还能对病变进行体内监测以及对脉络膜上腔进行药物递送监测。在此,我们讨论该潜在空间在医学和外科应用方面的最新进展。