绝经后女性膝关节骨关节炎与绝经激素治疗：一项全国性横断面研究。
Knee osteoarthritis and menopausal hormone therapy in postmenopausal women: a nationwide cross-sectional study.
机构信息
Korea University College of Medicine, Inchon-ro, Seongbuk-gu, Seoul, Korea.
Division of Rheumatology, Department of Internal Medicine, Korea University Guro Hospital, Gurodong-ro, Guro-gu, Seoul, Korea.
出版信息
Menopause. 2018 Dec 21;26(6):598-602. doi: 10.1097/GME.0000000000001280.
OBJECTIVE
The incidence of osteoarthritis (OA) increases after menopause, and may be related to hormonal changes in women. Estrogen deficiency is known to affect the development of OA, and menopausal hormone therapy (MHT) is suggested to be related to the development of OA. However, the relationship between knee OA and MHT remains controversial. The association between knee OA prevalence and MHT was investigated using large-scale national data.
METHODS
Data were collected from 4,766 postmenopausal women from the Korea National Health and Nutrition Examination Survey (2009-2012). MHT was defined as regular hormone medication for ≥1 year, and demographic and lifestyle variables were compared between the MHT and non-MHT groups. Knee OA was defined according to symptoms and radiographic findings.
RESULTS
In the multiple logistic regression models, the OA odds ratio was 0.70 for the MHT group (95% confidence interval 0.50-0.99), compared with the non-MHT group.
CONCLUSIONS
The prevalence of knee OA was lower in participants with MHT than in those without MHT.
目的
骨关节炎（OA）在绝经后发病率增加，可能与女性激素变化有关。雌激素缺乏已知会影响 OA 的发展，绝经激素治疗（MHT）被认为与 OA 的发展有关。然而，膝骨关节炎与 MHT 之间的关系仍存在争议。本研究使用大规模全国性数据探讨了膝骨关节炎患病率与 MHT 的关系。
方法
数据来自韩国国家健康和营养检查调查（2009-2012 年）的 4766 名绝经后妇女。MHT 定义为定期激素治疗≥1 年，比较 MHT 组和非 MHT 组的人口统计学和生活方式变量。根据症状和影像学表现定义膝骨关节炎。
结果
在多因素逻辑回归模型中，与非 MHT 组相比，MHT 组的 OA 比值比为 0.70（95%置信区间为 0.50-0.99）。
结论
与未接受 MHT 治疗的患者相比，接受 MHT 治疗的患者的膝骨关节炎患病率较低。
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