Department of Rheumatology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan 410008, People's Republic of China.
Department of Rheumatology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan 410008, People's Republic of China.
Metabolism. 2019 Apr;93:44-51. doi: 10.1016/j.metabol.2018.12.004. Epub 2018 Dec 23.
Systemic sclerosis (SSc) is an immune-mediated autoimmune disease characterized by fibrosis and vascular abnormalities. The cellular and molecular mechanisms remain unclear, and current therapies are limited. Cell metabolism has been shown to play an essential role in cancer survival and tumour invasion as well as in rheumatic diseases such as systemic lupus erythematosus, rheumatoid arthritis and osteoarthritis. Although little is known about SSc, cell metabolism may provide new clues for understanding its pathogenesis. In this review, we summarize recent studies of metabolism in SSc and fibrotic disease, specifically focusing on glycolysis, fatty acid metabolism and oxidative stress. We highlight the role of metabolism in fibroblast differentiation and emphasize its potential therapeutic prospects in SSc.
系统性硬化症（SSc）是一种免疫介导的自身免疫性疾病，其特征为纤维化和血管异常。其细胞和分子机制仍不清楚，目前的治疗方法也有限。细胞代谢已被证明在癌症存活和肿瘤侵袭以及红斑狼疮、类风湿关节炎和骨关节炎等风湿性疾病中发挥着重要作用。尽管对 SSc 知之甚少，但细胞代谢可能为理解其发病机制提供新的线索。在这篇综述中，我们总结了 SSc 和纤维化疾病中代谢的最新研究，特别是关注糖酵解、脂肪酸代谢和氧化应激。我们强调了代谢在成纤维细胞分化中的作用，并强调了其在 SSc 中的潜在治疗前景。
