Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany.
Exp Dermatol. 2014 Feb;23(2):99-100. doi: 10.1111/exd.12237.
LeRoy's seminal work on the phenotypic features of scleroderma fibroblasts has been directing fibrosis research in the field of systemic sclerosis (SSc, scleroderma) for the past 30 years. His principal experiment, to culture skin fibroblasts from patients with SSc and study their pro-fibrotic phenotype in comparison with skin fibroblasts from healthy individuals, has been used by most basic and translational fibrosis studies in SSc. LeRoy's findings have revolutionized our understanding of the disease pathogenesis and guided the development of novel antifibrotic therapies towards fibroblast-specific approaches.
勒罗伊关于硬皮病成纤维细胞表型特征的开创性工作，在过去的 30 年里一直指导着系统性硬皮病（SSc，硬皮病）领域的纤维化研究。他的主要实验是培养来自 SSc 患者的皮肤成纤维细胞，并与来自健康个体的皮肤成纤维细胞比较研究其致纤维化表型，这一实验被大多数 SSc 的基础和转化纤维化研究使用。勒罗伊的发现彻底改变了我们对疾病发病机制的理解，并指导了针对成纤维细胞特异性方法的新型抗纤维化治疗的发展。
