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综述:经皮肺动脉狭窄治疗:现状与未来展望

A review: Percutaneous pulmonary artery stenosis therapy: state-of-the-art and look to the future.

作者信息

Patel Anuj B, Ratnayaka Kanishka, Bergersen Lisa

机构信息

Division of Cardiology, Boston Children's Hospital, Boston, MA, USA.

Division of Cardiology, Rady Children's Hospital, San Diego, CA, USA.

出版信息

Cardiol Young. 2019 Feb;29(2):93-99. doi: 10.1017/S1047951118001087. Epub 2018 Dec 27.

Abstract

Stenosis, or narrowing, of the branches of the pulmonary artery is a type of CHD that, if left untreated, may lead to significant complications. Ideally, interventions to treat stenosis occur before significant complications or long-term sequelae take place, often within the first 2 years of life. Treatment depends on specifics of the condition, the presence of other malformations, and age of the child. Research and recent innovation to address these shortcomings have provided physicians with safer and more effective methods of treatment. This has further continued to push the ceiling of pulmonary arterial stenosis treatment available for patients. Despite continuous advancement in angioplasty - such as conventional and cutting balloon - and stenting, each treatment method is not without its unique limitations. New technological developments such as bioresorbable stents can accommodate patient growth and pulmonary artery stenosis treatment. As more than a decade has passed since the review by Bergersen and Lock, this article aims to provide a contemporary summary and investigation into the effectiveness of various therapeutic tools currently available, such as bare metal stents and potential innovations including bioresorbable stents.

摘要

肺动脉分支狭窄,即变窄,是一种先天性心脏病(CHD),如果不进行治疗,可能会导致严重的并发症。理想情况下,治疗狭窄的干预措施应在严重并发症或长期后遗症出现之前进行,通常在儿童出生后的头两年内。治疗方法取决于病情的具体情况、是否存在其他畸形以及患儿的年龄。针对这些不足的研究和最新创新为医生提供了更安全、更有效的治疗方法。这进一步推动了可用于患者的肺动脉狭窄治疗的上限。尽管血管成形术(如传统球囊和切割球囊)和支架置入术不断进步,但每种治疗方法都有其独特的局限性。生物可吸收支架等新技术的发展可以适应患者的生长并用于肺动脉狭窄的治疗。自伯格森和洛克发表综述以来,已经过去了十多年,本文旨在对目前可用的各种治疗工具(如裸金属支架)的有效性以及包括生物可吸收支架在内的潜在创新进行当代总结和研究。

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