Department of Microbiology and Immunology, SUNY Upstate Medical University, Syracuse, NY 13210;
Department of Chemistry, Syracuse University, Syracuse, NY 13244; and.
J Immunol. 2019 Jan 1;202(1):11-19. doi: 10.4049/jimmunol.1800991.
After decades of intense effort, therapeutics that leverage the immune system to fight cancer have now been conclusively demonstrated to be effective. Immuno-oncology has arrived and will play a key role in the treatment of cancer for the foreseeable future. However, the search for novel methods to improve immune responses to cancer continues unabated. Toward this end, small molecules that can either reduce immune suppression in the tumor milieu or enhance activation of cytotoxic lymphocyte responses to the tumor are actively being pursued. Such novel treatment strategies might be used as monotherapies or combined with other cancer therapies to increase and broaden their efficacy. In this article, we provide an overview of small molecule immunotherapeutic approaches for the treatment of cancer. Over the next decade and beyond, these approaches could further enhance our ability to harness the immune system to combat cancer and thus become additional weapons in the oncologist's armory.
经过几十年的努力，利用免疫系统对抗癌症的治疗方法已被证实是有效的。免疫肿瘤学已经到来，并将在可预见的未来在癌症治疗中发挥关键作用。然而，人们仍在不断寻找新的方法来提高对癌症的免疫反应。为此，人们正在积极探索能够减少肿瘤微环境中免疫抑制或增强细胞毒性淋巴细胞对肿瘤激活反应的小分子。这些新的治疗策略可以作为单一疗法使用，也可以与其他癌症疗法联合使用，以提高和扩大其疗效。在本文中，我们概述了用于治疗癌症的小分子免疫治疗方法。在未来十年及以后，这些方法可能会进一步增强我们利用免疫系统对抗癌症的能力，从而成为肿瘤学家武器库中的又一利器。
