Rustogi Deepika, Yadav Sangeeta, Ramji Siddarth, Mishra T K
Department of Pediatrics,Maulana Azad Medical College (University of Delhi), New Delhi, India.
Department of Pediatrics, Maulana Azad Medical College (University of Delhi), New Delhi, India. Correspondence to: Dr Sangeeta Yadav, Director Professor, Head, Department of Pediatrics, Maulana Azad Medical College, New Delhi, India.
Indian Pediatr. 2018 Nov 15;55(11):975-978.
Correlation of catch-up growth and Insulin-like Growth Factor -1 levels (IGF-I) in SGA babies.
50 Full-term Small for Gestational Age children aged 12-18 months were analyzed for Catch-up growth (gain in weight and/or length, Standard Deviation Score/SDS >0.67). IGF-1 was measured after post-glucose load using ELISA method and correlated with catch-up growth.
Mean (SD) birthweight and length were 2.1 (0.3) Kg and 44.4 (3.1) cm, respectively. At enrollment, mean (SD) age, weight and length were 15.0 (2.1) months, 7.7 (1.3) Kg, and 72.9 (5.6) cm, respectively. Catch-up growth was noted in 60% children. IGF-1 levels were significantly higher in children showing catch-up growth (56.6 (63.2) ng/mL) compared to those not having catch up growth (8.7 (8.3) ng/mL). IGF-1 was positively correlated with both weight and length catch-up.
Majority of Small for Gestational Age showed catch-up growth by 18 months, which had good correlation with IGF-1 levels.
探讨小于胎龄儿（SGA）的追赶生长与胰岛素样生长因子-1（IGF-I）水平之间的相关性。
对50名12至18个月大的足月小于胎龄儿进行分析，评估其追赶生长情况（体重和/或身长增加，标准差评分/SDS>0.67）。采用酶联免疫吸附测定法（ELISA）在葡萄糖负荷后测量IGF-1水平，并将其与追赶生长情况进行相关性分析。
平均（标准差）出生体重和身长分别为2.1（0.3）kg和44.4（3.1）cm。入组时，平均（标准差）年龄、体重和身长分别为15.0（2.1）个月、7.7（1.3）kg和72.9（5.6）cm。60%的儿童出现了追赶生长。与未出现追赶生长的儿童（8.7（8.3）ng/mL）相比，出现追赶生长的儿童IGF-1水平显著更高（56.6（63.2）ng/mL）。IGF-1与体重和身长的追赶均呈正相关。
大多数小于胎龄儿在18个月时出现追赶生长，这与IGF-1水平密切相关。
