Ellis M, Gupta S, Galant S, Hakim S, VandeVen C, Toy C, Cairo M S
Department of Medicine, School of Medicine, University of California, Irvine.
J Infect Dis. 1988 Dec;158(6):1268-76. doi: 10.1093/infdis/158.6.1268.
We measured the neutrophil function of 6 patients with AIDS and Kaposi's sarcoma (KS); 22 patients with AIDS-related complex (ARC); and 28 healthy, heterosexual controls. Neutrophils from patients with ARC showed significantly less chemotaxis (P less than or equal to .025) than did those from patients with AIDS and KS or from controls. Serum from patients with AIDS and KS or with ARC significantly (P less than or equal to .05) inhibited chemotaxis of neutrophils from controls; heat treatment of the serum abolished this inhibitory effect. Bacterial killing by neutrophils from patients with AIDS and KS or with ARC was also significantly (P less than or equal to .05) less than for neutrophils from controls, as was neutrophil phagocytosis binding of Candida albicans (P less than or equal to .05). Expression of OKM1 antigen was increased in the patients studied. Enzyme degranulation, adherence, and aggregation were also examined. The defects found in neutrophil function are selective and may be important in the increased susceptibility of patients with human immunodeficiency virus infection to bacterial and fungal infections.
我们检测了6例患有艾滋病和卡波西肉瘤（KS）的患者、22例患有艾滋病相关综合征（ARC）的患者以及28名健康异性恋对照者的中性粒细胞功能。与患有艾滋病和KS的患者或对照者相比，ARC患者的中性粒细胞趋化性显著降低（P≤0.025）。艾滋病和KS患者或ARC患者的血清显著（P≤0.05）抑制对照者中性粒细胞的趋化性；血清经热处理后这种抑制作用消失。艾滋病和KS患者或ARC患者的中性粒细胞对细菌的杀伤能力也显著（P≤0.05）低于对照者中性粒细胞，其对白色念珠菌的吞噬结合能力也显著降低（P≤0.05）。在所研究的患者中，OKM1抗原的表达增加。还检测了酶脱颗粒、黏附及聚集情况。发现的中性粒细胞功能缺陷具有选择性，可能对人类免疫缺陷病毒感染患者易患细菌和真菌感染具有重要意义。
