降低新生儿重症监护病房导管相关血流感染的预防性集束措施。
Preventive bundles to reduce catheter-associated bloodstream infections in neonatal intensive care.
作者信息
Schmid Sarah, Geffers Christine, Wagenpfeil Gudrun, Simon Arne
机构信息
University Hospital of the Saarland, Children's Hospital, Pediatric Oncology and Hematology, Homburg, Germany.
German National Reference Center for Surveillance of Nosocomial Infections, Institute for Hygiene and Environmental Medicine, Charité-Universitätsmedizin Berlin, Germany.
出版信息
GMS Hyg Infect Control. 2018 Nov 16;13:Doc10. doi: 10.3205/dgkh000316. eCollection 2018.
This systematic survey includes a total of 27 studies published between 2002 and 2016 on the benefit of preventive bundles for the prevention of central-line associated bloodstream infections (CLABSI) in neonatal intensive care. These studies are mainly cohort studies or studies analyzing an interrupted time series before and after intervention. The studies showed heterogeneity in terms of endpoint definitions (CLABSI), details of the implemented measures, and evidence of a publication bias favoring the use of of preventive bundles. The cumulative analysis showed a statistically and clinically significant benefit of preventive bundles to avoid CLABSI in neonatal intensive care.
这项系统综述共纳入了27项于2002年至2016年间发表的研究，这些研究探讨了预防性集束措施在新生儿重症监护中预防中心静脉导管相关血流感染（CLABSI）的益处。这些研究主要为队列研究或分析干预前后中断时间序列的研究。这些研究在终点定义（CLABSI）、实施措施的细节以及支持使用预防性集束措施的发表偏倚证据方面存在异质性。累积分析表明，预防性集束措施在新生儿重症监护中预防CLABSI具有统计学和临床意义上的显著益处。
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