糖尿病视网膜病变患者脉络膜、视网膜外层及视网膜色素上皮层的厚度和体积会发生变化。
The thickness and volume of the choroid, outer retinal layers and retinal pigment epithelium layer changes in patients with diabetic retinopathy.
作者信息
Wang Xiang-Ning, Li Shu-Ting, Li Wei, Hua Yan-Jun, Wu Qiang
机构信息
Department of Ophthalmology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China.
Shanghai Key Laboratory of Diabetes Mellitus, Shanghai 200233, China.
出版信息
Int J Ophthalmol. 2018 Dec 18;11(12):1957-1962. doi: 10.18240/ijo.2018.12.14. eCollection 2018.
AIM
To evaluate the thickness and volume changes of the choroidal, outer retinal layers (ORL) and retinal pigment epithelium (RPE) in patients with diabetic retinopathy (DR) using optical coherence tomography (OCT) and correlate them with visual acuity.
METHODS
We carried out a retrospective observational case series. Consecutive DR patients were recruited for color fundus photography and OCT assessment. The RPE, ORL and choroidal thickness were measured. The correlation with the best-corrected visual acuity (BCVA) was also investigated.
RESULTS
The study included 128 eyes, comprising 45 eyes of 25 diabetic macular edema (DME) patients, 34 eyes of 20 DR without DME (non-DME) patients, and 49 eyes of 25 age-matched normal individuals. The choroidal thickness in DR patients were decreased statistically significantly compared with the control group (<0.05). The mean macular ORL thickness in DME (73.02±15.34 µm) and non-DME groups (76.35±7.32 µm) were decreased statistically significantly compared with the control group (80.20±5.85 µm; =0.006, =0.013, respectively). In both the non-DME and DME groups, the RPE thickness were decreased compared with the control group (<0.05), except in the macular and central ring. The BCVA were significant interactions with the total inner retinal volume and macular RPE thickness in the DME group (=0.115, <0.001, =-0.013, =0.017, respectively).
CONCLUSION
The choroid, ORL and RPE thickness are significantly decreased in DR patients compared with controls in different segments.
目的
使用光学相干断层扫描（OCT）评估糖尿病视网膜病变（DR）患者脉络膜、视网膜外层（ORL）和视网膜色素上皮（RPE）的厚度及体积变化，并将其与视力相关联。
方法
我们进行了一项回顾性观察病例系列研究。连续纳入DR患者进行彩色眼底照相和OCT评估。测量RPE、ORL和脉络膜厚度。还研究了与最佳矫正视力（BCVA）的相关性。
结果
该研究包括128只眼，其中25例糖尿病性黄斑水肿（DME）患者的45只眼，20例无DME的DR（非DME）患者的34只眼，以及25例年龄匹配的正常个体的49只眼。DR患者的脉络膜厚度与对照组相比有统计学显著降低（<0.05）。DME组（73.02±15.34 µm）和非DME组（76.35±7.32 µm）的平均黄斑ORL厚度与对照组（80.20±5.85 µm）相比有统计学显著降低（分别为=0.006，=0.013）。在非DME组和DME组中，除黄斑和中央环外，RPE厚度与对照组相比均降低（<0.05）。在DME组中，BCVA与总视网膜内体积和黄斑RPE厚度有显著交互作用（分别为=0.115，<0.001，=-0.013，=0.017）。
结论
与对照组相比，DR患者不同节段的脉络膜、ORL和RPE厚度均显著降低。
Zotero 插件