Sun Lingjuan, Yin Li, Wang Shurui, Wang Haiyan
Department of Ophthalmology Shijiazhuang People's Hospital, Shijiazhuang, Hebei 050000, China.
J Ophthalmol. 2024 Sep 19;2024:9322594. doi: 10.1155/2024/9322594. eCollection 2024.
This study aimed to investigate the risk factors associated with central serous chorioretinopathy (CSC) and analyze the relationship between vascular endothelial growth factor (VEGF), high-sensitivity C-reactive protein (hs-CRP), erythrocyte sedimentation rate (ESR), and CSC.
A total of 109 patients diagnosed with CSC (CSC group) at our ophthalmology clinic from February 2017 to February 2021 were included, with 103 volunteers from our hospital's health examination center serving as the control group. Additionally, the new multimodal imaging classification of 109 CSC patients was further divided into simple CSC (57 cases) and complex CSC (52 cases). Demographic data, underlying diseases, medical history, and medication history were collected. Levels of VEGF, hs-CRP, and ESR were measured, and multifactorial logistic regression analysis was performed to identify factors influencing CSC. Receiver operating characteristic (ROC) curve analysis was conducted to assess the diagnostic value of VEGF, hs-CRP, and ESR in CSC.
The CSC group showed a higher proportion of males, smoking history, alcohol consumption, comorbid obstructive sleep apnea, hypothyroidism, renal disease, infection, steroid use, and shift work compared to the control group ( < 0.05). VEGF, hs-CRP, and ESR levels were significantly higher in the CSC group than in the control group ( < 0.05). The levels of VEGF, hs-CRP, and ESR in the complex CSC group were higher than those in the simple CSC group ( < 0.05). Male gender, shift work, infection, hypothyroidism, elevated VEGF, hs-CRP, and ESR were identified as risk factors for CSC ( < 0.05). The combined diagnostic value of VEGF, hs-CRP, and ESR (area under the ROC curve: 0.886) was higher than that of individual markers (0.722, 0.728, and 0.703, respectively) ( < 0.05).
Male gender, shift work, infection, hypothyroidism, and elevated levels of VEGF, hs-CRP, and ESR are risk factors for CSC. The combined use of VEGF, hs-CRP, and ESR demonstrates higher diagnostic efficiency in identifying CSC.
本研究旨在调查与中心性浆液性脉络膜视网膜病变（CSC）相关的危险因素，并分析血管内皮生长因子（VEGF）、高敏C反应蛋白（hs-CRP）、红细胞沉降率（ESR）与CSC之间的关系。
纳入2017年2月至2021年2月在我院眼科门诊确诊为CSC的109例患者（CSC组），选取我院健康体检中心的103名志愿者作为对照组。此外，将109例CSC患者的新多模态影像分类进一步分为单纯性CSC（57例）和复杂性CSC（52例）。收集人口统计学数据、基础疾病、病史和用药史。检测VEGF、hs-CRP和ESR水平，并进行多因素logistic回归分析以确定影响CSC的因素。进行受试者操作特征（ROC）曲线分析以评估VEGF、hs-CRP和ESR在CSC中的诊断价值。
与对照组相比，CSC组男性比例、吸烟史、饮酒、合并阻塞性睡眠呼吸暂停、甲状腺功能减退、肾脏疾病、感染、使用类固醇和轮班工作的比例更高（<0.05）。CSC组的VEGF、hs-CRP和ESR水平显著高于对照组（<0.05）。复杂性CSC组的VEGF、hs-CRP和ESR水平高于单纯性CSC组（<0.05）。男性、轮班工作、感染、甲状腺功能减退、VEGF、hs-CRP和ESR升高被确定为CSC的危险因素（<0.05）。VEGF、hs-CRP和ESR的联合诊断价值（ROC曲线下面积：0.886）高于单个标志物（分别为0.722、0.728和0.703）（<0.05）。
男性、轮班工作、感染、甲状腺功能减退以及VEGF、hs-CRP和ESR水平升高是CSC的危险因素。联合使用VEGF、hs-CRP和ESR在识别CSC方面具有更高的诊断效率。
