Liang Yansong, Di Xuemin, Liu Zezhou, Zhao Jinxin, Wang Zeyang, Zhao Jing, Sui Aixia, Zhang Hongtao, Wang Juan
Graduate School of Hebei Medical University, Shijiazhuang, Hebei Province, China.
Department of Oncology, The Hebei General Hospital, Shijiazhuang, Hebei Province, China.
J Cancer Res Ther. 2018;14(7):1660-1664. doi: 10.4103/jcrt.JCRT_1032_17.
The skin squamous cell carcinoma (SCC) is a kind of malignancy of keratinocytes. SCC was originated within the epidermis or relevant appendages, which commonly occurred on sunlight exposure sites, such as the head and neck. This case report described an 85-year-old female patient with skin SCC at the right frontal, accompanied with skin ulcer. This patient suffered from indications that were not suitable for surgical resection, including old age, Alzheimer's disease (AD), lacunar infarction, hydropericardium, and some other concomitant diseases. In addition, the external beam radiotherapy was rejected by the relatives of this patient. Then, the patient received I seeds interstitial brachytherapy guided by bedside ultrasound. The tumor response was evaluated based on the response evaluation criteria in solid tumors version 1.1 criteria. Complete response was achieved 4 months after brachytherapy. No complications and recurrence were observed during 8-month follow-up. As the sole modality, the I seeds implantation could be a reasonable and safe alternative for treating skin SCC with ulcer, especially for the elderly patients.
皮肤鳞状细胞癌（SCC）是一种角质形成细胞的恶性肿瘤。SCC起源于表皮或相关附属器，常见于阳光暴露部位，如头颈部。本病例报告描述了一名85岁女性患者，右额部患有皮肤SCC，并伴有皮肤溃疡。该患者存在一些不适合手术切除的指征，包括高龄、阿尔茨海默病（AD）、腔隙性脑梗死、心包积液以及其他一些伴随疾病。此外，患者家属拒绝了外照射放疗。随后，该患者接受了床边超声引导下的碘籽源组织间近距离放疗。根据实体瘤疗效评价标准1.1版标准评估肿瘤反应。近距离放疗4个月后达到完全缓解。在8个月的随访期间未观察到并发症和复发。作为单一治疗方式，碘籽源植入对于治疗伴有溃疡的皮肤SCC可能是一种合理且安全的替代方法，尤其适用于老年患者。
