1 Infectious Disease Unit, 3rd Department of Pediatrics, Medical Faculty, Aristotle University School of Health Sciences, Hippokration General Hospital, Thessaloniki, Greece.
2 Microbiology Department, Hippokration General Hospital, Thessaloniki, Greece.
Microb Drug Resist. 2019 Jun;25(5):712-716. doi: 10.1089/mdr.2018.0266. Epub 2018 Dec 27.
The molecular epidemiology of endemic carbapenem-resistant (CRKP), carbapenem-resistant (CRPA), and carbapenem-resistant (CRAB) in an intensive care unit located in an endemic area with high rates of resistance was investigated. A CRPA strain producing VIM and KPC concurrently was detected for the first time in an endemic area. CRKP strains producing carbapenemase predominated and were mainly assigned to the "hyperepidemic Greek clone." Predominant OXA-23-like producing CRAB strains were assigned to multiple pulsotypes.
本研究调查了位于耐药率较高的流行地区的重症监护病房中地方性耐碳青霉烯类肠杆菌科（CRKP）、耐碳青霉烯类肺炎克雷伯菌（CRPA）和耐碳青霉烯类鲍曼不动杆菌（CRAB）的分子流行病学。首次在流行地区检测到一株同时产 VIM 和 KPC 的耐碳青霉烯类肺炎克雷伯菌。产碳青霉烯酶的 CRKP 菌株占主导地位，主要被归属于“高度流行的希腊克隆”。主要产 OXA-23 型的耐碳青霉烯类鲍曼不动杆菌菌株被分配到多个脉冲场凝胶电泳型。
