Sambrook P N, Eisman J A, Pocock N A, Jenkins A B
Garvan Institute of Medical Research, St. Vicent's Hospital, Darlinghurst, NSW, Australia.
J Rheumatol. 1988 Sep;15(9):1415-7.
A relationship between circulating insulin and bone mass has been postulated. To test this hypothesis we measured fasting serum insulin and quantitated bone density in the forearm, spine and femoral neck by single and dual photon absorptiometry of 70 normal women. There was no statistically significant relationship between insulin and bone density at any site by correlation or regression analysis. Although the relationship between a single measurement of a hormone (at one point in time) and bone density (the result of lifelong factors) should be interpreted with caution, our findings do not support the hypothesis that there is an association between serum insulin and bone mass.
循环胰岛素与骨量之间的关系已被提出。为了验证这一假设，我们测量了70名正常女性的空腹血清胰岛素，并通过单光子和双光子吸收测定法对前臂、脊柱和股骨颈的骨密度进行了定量分析。通过相关性或回归分析，胰岛素与任何部位的骨密度之间均无统计学上的显著关系。尽管对一种激素（在某一时刻）的单次测量与骨密度（终身因素的结果）之间的关系应谨慎解读，但我们的研究结果并不支持血清胰岛素与骨量之间存在关联的假设。
