Department of Radiation Oncology, University of Virginia, Charlottesville, VA, 22908, USA.
Department of Physics, University of Virginia, Charlottesville, VA, 22904, USA.
Med Phys. 2019 Feb;46(2):868-876. doi: 10.1002/mp.13362. Epub 2019 Jan 21.
With increasing cancer treatment success rates, many patients go on to live long, productive lives following recovery. Therefore, minimizing potential side effects due to dose outside the treated field is becoming a significant consideration in radiation therapy. With many potential treatment configurations available, it is important to quantify how out-of-field dose varies with common variables such as distance from isocenter, couch angle, jaw size, and flattening-filter setting. The accurate quantification of out-of-field dose at extended distances could also benefit researchers and detector developers. While data exist for out-of-field dose from older linear accelerator (Linac) models, the phenomenon has not been described for the latest generation of machines, such as the Varian TrueBeam. The purpose of this study was to comprehensively quantify out-of-field dose for the Varian TrueBeam Linac low energy photons in a wide range of positions and treatment geometries.
Out-of-field doses were measured using two phantom setups: (a) A large volume ion chamber with a buildup sleeve to quantify head leakage and collimator scatter background dose; and (b) A farmer ion chamber in solid water to incorporate phantom scatter in addition to collimator scatter, and head leakage background dose. In both cases, the ion chamber was positioned with its length along the slowly varying transverse direction (perpendicular to the radial from isocenter). Doses were measured for four symmetric jaw settings (2 × 2 cm , 4 × 4 cm , 10 × 10 cm , and 20 × 20 cm ) for a range of distances from the isocenter (0-100 cm). The angular dependence of the out-of-field dose was measured using four different angles: 0°, 45°, 90°, and 135° with respect to the in-plane direction. All measurements were performed for both 6X and 6X-flattening-filter-free (FFF) beams.
The lowest out-of-field doses were observed at 60 cm away from isocenter in both in-plane and cross-plane directions for fields smaller than 10 × 10 cm . Out-of-field dose decreased with decreasing jaw size (a factor of 4.7 for 6X-FFF and a factor of 3.1 for 6X going from 20 × 20 cm to 2 × 2 cm at 60 cm from isocenter in the in-plane direction). The 6X-FFF beam produced out-of-field doses as low as 64% of the 6X beam.
This study presents a comprehensive description of 6X and 6X-FFF out-of-field doses on a Varian TrueBeam Linac including measurements at a range of positions, angles, and jaw settings and with and without phantom scatter.
随着癌症治疗成功率的提高,许多患者在康复后能够长期、健康地生活。因此,最大限度地减少因剂量超出治疗野而导致的潜在副作用,在放射治疗中变得越来越重要。由于有许多潜在的治疗方案可供选择,因此量化治疗野外剂量如何随距离等中心的距离、治疗床角度、准直器大小和均整滤过器设置等常见变量而变化是很重要的。在更远的距离准确量化治疗野外剂量也将使研究人员和探测器开发人员受益。虽然有旧的直线加速器(Linac)模型的治疗野外剂量数据,但尚未描述最新一代机器(如瓦里安 TrueBeam)的这种现象。本研究的目的是全面量化瓦里安 TrueBeam Linac 低能光子在广泛的位置和治疗几何形状下的治疗野外剂量。
使用两种体模设置测量治疗野外剂量:(a)带有累积套的大容积电离室,用于量化头部泄漏和准直器散射背景剂量;(b)固体水中的 Farmer 电离室,用于合并准直器散射和头部泄漏背景剂量。在这两种情况下,电离室的长度都沿着横向缓慢变化的方向(垂直于从等中心的径向)放置。对于从等中心(0-100cm)的距离范围内的四个对称准直器设置(2×2cm、4×4cm、10×10cm 和 20×20cm),测量剂量。使用四个不同的角度(0°、45°、90°和 135°)测量治疗野外剂量的角度依赖性,相对于平面内方向。所有测量均针对 6X 和 6X-无均整滤过器自由(FFF)光束进行。
在平面内和交叉平面内,距离等中心 60cm 处观察到的治疗野外剂量最小,对于小于 10×10cm 的射野。治疗野外剂量随准直器尺寸的减小而减小(在平面内方向,60cm 处,6X-FFF 为 4.7 倍,6X 为 3.1 倍,从 20×20cm 减小到 2×2cm)。6X-FFF 束产生的治疗野外剂量低至 6X 束的 64%。
本研究全面描述了瓦里安 TrueBeam Linac 上的 6X 和 6X-FFF 治疗野外剂量,包括在一系列位置、角度和准直器设置下的测量,以及有无体模散射的情况。