Department of Radiological Physics, SP Medical college, Bikaner, Rajasthan, India.
Swasthya Kalyan group of Institutions, Jaipur, Rajasthan, India.
Asian Pac J Cancer Prev. 2024 May 1;25(5):1529-1538. doi: 10.31557/APJCP.2024.25.5.1529.
To evaluate the out-of-field dose associated with flattened (FF) and flattening filter-free (FFF) 6 and 10 MV X-ray beams in a TrueBeam linear accelerator (Linac).
Measurements were taken in a slab phantom using the metal oxide semiconductor field effect transistor (MOSFET) detector at varying depths (dmax, 5 cm, and 10 cm) for clinically relevant field sizes and up to 30 cm from the field edges for 6 and 10 MV FF and FFF beams in TrueBeam Linac. Dose calculation accuracy of the analytic anisotropic algorithm (AAA) and Acuros algorithm was investigated in the out-of-field region. Similarly, the out-of-field dose associated with volumetric modulated arc therapy (VMAT) head-and-neck plan delivered to a body phantom was evaluated.
The out-of-field dose for both FF and FFF photon beams (6 and 10 MV) decreased with increasing distance from the field boundary and size. Furthermore, regardless of FF in the field, higher-energy photon beams were associated with lower out-of-field dose. Both algorithms underestimated the dose in the out-of-field region, with AAA failing to calculate the out-of-field dose at 15 cm from the field edge and Acuros failing to calculate out-of-field radiation at 20 cm. At 5 cm from the field edge, an average of 50% underestimation was observed, and at 10 cm, an average of 60% underestimation was observed for both FF and FFF (6 and 10 MV) beams. The VMAT head-and-neck plan performed with the FFF beam resulted in a lower out-of-field dose than the FF beam for a comparable dose distribution.
Compared with flattened beams, the FFF modes on TrueBeam Linac exhibited a clinically relevant reduction in the out-of-field dose. Further dosimetric studies are warranted to determine the significant benefit of FFF beams across different cancer sites.
评估在 TrueBeam 直线加速器中,平坦化(FF)和非平坦化滤波(FFF)6 和 10MV X 射线束的场外剂量。
在平板体模中使用金属氧化物半导体场效应晶体管(MOSFET)探测器进行测量,针对临床相关射野大小,在不同深度(dmax、5cm 和 10cm)以及离射野边缘 30cm 处,测量 6 和 10MV FF 和 FFF 射线束的场外剂量。在射场外区域,研究了解析各向异性算法(AAA)和 Acuros 算法的剂量计算准确性。同样,还评估了体部模体上容积调强弧形治疗(VMAT)头颈部计划相关的场外剂量。
对于 FF 和 FFF 光子束(6 和 10MV),场外剂量均随离射野边界和射野尺寸的增加而降低。此外,无论场中是否存在 FF,高能光子束的场外剂量均较低。两种算法均低估了射场外区域的剂量,AAA 无法计算离射野边缘 15cm 处的场外剂量,而 Acuros 无法计算离射野边缘 20cm 处的辐射剂量。在离射野边缘 5cm 处,平均低估了 50%,在离射野边缘 10cm 处,FF 和 FFF(6 和 10MV)束的平均低估率为 60%。对于相似的剂量分布,使用 FFF 射线束的 VMAT 头颈部计划产生的场外剂量低于 FF 射线束。
与平坦化束相比,TrueBeam 直线加速器的 FFF 模式在临床上显著降低了场外剂量。需要进一步的剂量学研究来确定 FFF 射线束在不同癌症部位的显著优势。