a Department of Neurology , Beni-Suef University , Beni-Suef , Egypt.
b Department of Anaesthesia , Intensive Care and Pain Management, Beni-Suef University , Beni-Suef , Egypt.
Int J Neurosci. 2019 Aug;129(8):729-737. doi: 10.1080/00207454.2018.1561451. Epub 2019 Feb 20.
There is alarming evidence about the involvement of general anaesthesia in the development of postoperative cognitive dysfunction. To clarify the impact of general anaesthesia on cognitive function and to study the possible effect of general anaesthesia on serum S100B, the marker of neuronal degeneration. This is a prospective randomised controlled study carried out on 50 patients undergoing elective laparoscopic cholecystectomy under conventional general anaesthesia. Cognitive assessment for selected patients was done preoperative and 1 week postoperative using Paired Associate Learning test (PALT) for assessment of verbal memory and Benton Visual Retention test (BVRT) for assessment of visual memory. Quantitative determination of serum S100B was done for all patients in the basal sample and postoperative sample by applying an enzyme- linked immunoabsorbent assay technique on am automated ELISA platform. Regarding cognitive tests, there was a statistically significant difference between the mean value of preoperative PALT and postoperative PALT (-value = .012). There was also a statistically significant difference between the mean value of preoperative BVRT and postoperative BVRT (-value = .011). Regarding S100B, there was a statistically significant difference between preoperative and postoperative serum level (-value = .002). There was also a statistically significant negative correlation between postoperative S100B serum level and the postoperative scores of both PALT and BVRT. General anaesthesia is incriminated in the development of postoperative verbal and visual memory impairment and in the postoperative increase in serum S100B, the markers of neuronal degeneration.
有令人震惊的证据表明全身麻醉会导致术后认知功能障碍。为了阐明全身麻醉对认知功能的影响，并研究全身麻醉对神经元退行性变标志物血清 S100B 的可能影响，我们进行了一项前瞻性随机对照研究，纳入了 50 例行择期腹腔镜胆囊切除术的患者，这些患者接受常规全身麻醉。对部分患者在术前和术后 1 周使用成对关联学习测试（PALT）评估言语记忆和宾顿视觉保持测试（BVRT）评估视觉记忆进行认知评估。通过在自动化 ELISA 平台上应用酶联免疫吸附测定技术，对所有患者的基础样本和术后样本进行血清 S100B 的定量测定。关于认知测试，术前 PALT 和术后 PALT 的平均值之间存在统计学差异（-值=0.012）。术前 BVRT 和术后 BVRT 的平均值之间也存在统计学差异（-值=0.011）。关于 S100B，术前和术后血清水平之间存在统计学差异（-值=0.002）。术后 S100B 血清水平与 PALT 和 BVRT 的术后评分之间存在统计学上的负相关。全身麻醉会导致术后言语和视觉记忆损伤，以及术后血清 S100B（神经元退行性变的标志物）升高。
