The New York State Psychiatric Institute/Columbia, University Medical Center, New York, NY, USA.
Neuropsychopharmacology. 2019 Apr;44(5):907-914. doi: 10.1038/s41386-018-0304-5. Epub 2018 Dec 27.
In a previously reported longitudinal study of violent ideation (VI) and violent behavior (VB) among 200 youths at clinical high-risk (CHR) for psychosis, we found that VI, hitherto underinvestigated, strongly predicted transition to first-episode psychosis (FEP) and VB, in close temporal proximity. Here, we present participants' baseline characteristics, examining clinical and demographic correlates of VI and VB. These participants, aged 13-30, were examined at Columbia University Medical Center's Center of Prevention and Evaluation, using clinical interviews and the structured interview for psychosis-risk syndromes (SIPS). At the onset of our longitudinal study, we gathered demographics, signs and symptoms, and descriptions of VI and VB. One-third of participants reported VI (n = 65, 32.5%) at baseline, experienced as intrusive and ego-dystonic, and associated with higher suspiciousness and overall positive symptoms. Less than one-tenth reported VB within 6 months of baseline (n = 17, 8.5%), which was unrelated to SIPS-positive symptoms, any DSM diagnosis or other clinical characteristic. The period from conversion through post-FEP stabilization may be characterized by heightened risk of behavioral disinhibition and violence. We provide a preliminary model of how violence risk may peak at various points in the course of psychotic illness.
在之前报道的一项针对 200 名处于精神病临床高危状态 (CHR) 的青少年暴力意念 (VI) 和暴力行为 (VB) 的纵向研究中,我们发现,迄今为止研究较少的 VI 强烈预测了首发精神病 (FEP) 和 VB 的发生,并与时间密切相关。在此,我们介绍了参与者的基线特征,研究了 VI 和 VB 与临床和人口统计学因素的相关性。这些年龄在 13 至 30 岁之间的参与者在哥伦比亚大学医学中心的预防与评估中心接受了检查,使用了临床访谈和精神病风险综合征结构化访谈 (SIPS)。在我们的纵向研究开始时,我们收集了参与者的人口统计学数据、体征和症状,以及 VI 和 VB 的描述。三分之一的参与者在基线时报告了 VI(n=65,32.5%),表现为侵入性和自我扭曲,并与更高的怀疑和总体阳性症状有关。不到十分之一的参与者在基线后 6 个月内报告了 VB(n=17,8.5%),这与 SIPS 阳性症状、任何 DSM 诊断或其他临床特征无关。从转化到 FEP 稳定后的时期可能以行为抑制和暴力风险增加为特征。我们提供了一个初步的模型,说明暴力风险如何在精神病病程的不同阶段达到峰值。