Mossetti G, Salomone Megna A, Maddaloni D, Motti C, Gravina E
Università degli Studi di Napoli - II Facoltà di Medicina e Chirurgia.
Minerva Med. 1988 Nov;79(11):931-6.
Plasma renin exists in an active form or as an inactive zymogen (P.P.) which is converted into active enzyme by exposure to trypsin. Inactive renin was first shown to be increased in patients with diabetes mellitus by Bye et al. The relationship between microalbuminuria (M.A.) in diabetic patients and the level of plasma inactive renin activated by trypsin was examined. The patients were divided into two groups: 1st group (Albustix+) and 2nd group (Albustix-). In the 1st group the inactive renin was greatly increased. In the patients with Albustix- albuminuria was measured by the R.I.A. method and two subgroups were identified. In the patients with albumin excretion over 40 mg/24 hr, prorenin was increased and correlated directly (r = 0.60) with M.A. In the group with albumin excretion below 40 mg/24 hr prorenin was normal except in three patients with increased M.A. These findings suggest that increased plasma prorenin levels in uncomplicated diabetes could anticipate the development of overt nephropathies.
血浆肾素以活性形式存在，或作为无活性的酶原（P.P.），通过接触胰蛋白酶转化为活性酶。拜伊等人首次发现糖尿病患者体内无活性肾素增加。研究了糖尿病患者微量白蛋白尿（M.A.）与经胰蛋白酶激活的血浆无活性肾素水平之间的关系。患者分为两组：第一组（尿蛋白试纸阳性）和第二组（尿蛋白试纸阴性）。第一组中无活性肾素大幅增加。在尿蛋白试纸阴性的患者中，通过放射免疫分析法测量白蛋白尿，并确定了两个亚组。在白蛋白排泄量超过40mg/24小时的患者中，肾素原增加，且与微量白蛋白尿直接相关（r = 0.60）。在白蛋白排泄量低于40mg/24小时的组中，除了三名微量白蛋白尿增加的患者外，肾素原正常。这些发现表明，在无并发症的糖尿病中，血浆肾素原水平升高可能预示着显性肾病的发展。
