Misbin R I, Grant M B, Pecker M S, Atlas S A
J Clin Endocrinol Metab. 1987 May;64(5):964-8. doi: 10.1210/jcem-64-5-964.
We measured plasma inactive renin (prorenin) levels in 46 diabetic patients, 4 nondiabetic patients with idiopathic autonomic dysfunction, and 115 normal subjects. Plasma inactive renin levels were normal in the diabetic patients who had no complications (n = 6) and in those with microvascular disease (n = 8) who did not have coexistent autonomic dysfunction. Plasma inactive renin was either grossly elevated or in the upper limit of the normal range in diabetic patients with autonomic dysfunction (n = 18). No correlation was found between plasma inactive renin and glycemic control, as measured by hemoglobin A1c. High plasma inactive renin levels were also found in the 4 nondiabetic patients with idiopathic autonomic dysfunction. These data suggest that increased plasma inactive renin levels in diabetic patients are a consequence of coexistent autonomic dysfunction. This finding is consistent with other evidence that suggests autonomic regulation of the processing of prorenin to renin within the kidney.
我们检测了46例糖尿病患者、4例患有特发性自主神经功能障碍的非糖尿病患者以及115名正常受试者的血浆无活性肾素（肾素原）水平。无并发症的糖尿病患者（n = 6）以及患有微血管疾病但无并存自主神经功能障碍的患者（n = 8），其血浆无活性肾素水平正常。患有自主神经功能障碍的糖尿病患者（n = 18），其血浆无活性肾素要么显著升高，要么处于正常范围的上限。通过糖化血红蛋白测定，未发现血浆无活性肾素与血糖控制之间存在相关性。在4例患有特发性自主神经功能障碍的非糖尿病患者中也发现了高血浆无活性肾素水平。这些数据表明，糖尿病患者血浆无活性肾素水平升高是并存自主神经功能障碍的结果。这一发现与其他证据一致，这些证据表明肾脏内肾素原转化为肾素的过程受自主神经调节。
