Monnard C, Vernet M
Laboratoire de Biochimie, Hôpital de la Croix-Rousse, Lyon, France.
Pathol Biol (Paris). 1988 Sep;36(7):933-9.
Lactoferrin and transferrin exhibit very similar structure and biochemical properties but they behave as two distinct antigens and their affinity for ferric ions is not of the same magnitude. The biological functions of lactoferrin are not all well understood. It has strong bacteriostatic properties, it plays a role as a regulator of human granulopoiesis and it is probably involved in the hyposideremia of acute inflammation. Measurement of lactoferrin was first applied in pancreatic juice or duodenal fluid as a diagnostic tool for pancreatic diseases. More recently plasma lactoferrin has been used as an index of total circulating neutrophil pool in hematological disorders and in uremic patients during hemodialysis. Its clinical usefulness is still discussed for the early diagnostic of infectious diseases.
乳铁蛋白和转铁蛋白具有非常相似的结构和生化特性，但它们表现为两种不同的抗原，并且它们对铁离子的亲和力大小不同。乳铁蛋白的生物学功能尚未完全明确。它具有很强的抑菌特性，在人类粒细胞生成中起调节作用，并且可能与急性炎症的低铁血症有关。乳铁蛋白的检测最初应用于胰液或十二指肠液中，作为胰腺疾病的诊断工具。最近，血浆乳铁蛋白已被用作血液系统疾病和血液透析期间尿毒症患者总循环中性粒细胞池的指标。其在传染病早期诊断中的临床实用性仍在讨论中。
