In vivo distribution of carrier protein/67Ga-complexes.
作者信息
Anghileri L J, Ottaviani M, Raynaud C
出版信息
Nuklearmedizin. 1982 Feb;21(1):8-11.
PMID:6952161
Abstract
The uptake of 67Ga as citrate, chloride and complexed by carrier-proteins (lactoferrin and transferrin) has been studied in tumor- and inflammatory lesion-bearing rats. Different uptake patterns are shown by tumors and lesions. 67Ga-transferrin complexes are taken up to the highest extent by tumors and inflammatory lesions. The comparative distribution studies using normal animals indicate a systemic increase of 67Ga uptake by tumor- and lesion-bearing animals which might be of importance in explaining the mechanism of 67Ga accumulation. The role of ionic environment changes and radioactivity concentration by isomorphous ionic replacement is discussed.
摘要
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