Kirpichenkova E V, Korolev A A, Onishchenko G G, Nikitenko E I, Lipatov D V, Kuz'min A G, Dyskin Yu A, Denisova E L, Fetisov R N
I.M. Sechenov First Moscow State Medical University (Sechenov University).
Endocrinology Research Centre, Moscow.
Vopr Pitan. 2018;87(5):20-26. doi: 10.24411/0042-8833-2018-10049. Epub 2018 Sep 13.
Lutein and zeaxanthin are carotenoid pigments that affect the function of the visual analyzer. They selectively accumulate in the yellow spot of the retina, form macular pigment and determine the density of the retina macula. Lutein and zeaxanthin slow down the progression of age-related macular degeneration, a leading cause of senior-age blindness. The main food sources of non-vitamin carotenoids are green leafy vegetables, zucchini, pumpkin, green peas, broccoli. The aim of the study is a retrospective assessment of the levels and sources of alimentary intake of lutein and zeaxanthin in young people and research of the effect of lutein and zeaxanthin in the diet on macula density. A specially designed questionnaire was used to quantify the content of lutein and zeaxanthin in the diet, reflecting the amount of consumption of the main sources of these carotenoids on the day preceding the survey. A non-invasive non-contact method of optical coherence tomography of the retina was used to determine the density of the macula. The study involved 96 students of Sechenov University at the age of 21-27 years. The study found that only 6.25% of the respondents had daily intake of lutein and zeaxanthin of 6 mg or more, 8.33% had 4.6-5.9 mg, 8.33% had 3.0-4.5 mg, in 18.75% - 1.5-2.9 mg, in 45.83% <1.4 mg. 12.5% of respondents didn't include sources of lutein and zeaxanthin in the diet. The more common sources of lutein and zeaxanthin in the diet were eggs and fresh tomatoes. Retinal density indices corresponded to the age standards in the majority of the examined. In 8.3% surveyed the thickness of the retina was decreased, and 4.2% had higher thickness of the retina in comparison with the standards. Significant differences in the Central subfield thickness in men and women were revealed. There was no dependence of the levels of lutein and zeaxanthin coming from food sources on the retina thickness indicators.
叶黄素和玉米黄质是影响视觉分析器功能的类胡萝卜素色素。它们选择性地积聚在视网膜的黄斑中,形成黄斑色素并决定视网膜黄斑的密度。叶黄素和玉米黄质可减缓年龄相关性黄斑变性的进展,年龄相关性黄斑变性是老年人失明的主要原因。非维生素类胡萝卜素的主要食物来源是绿叶蔬菜、西葫芦、南瓜、青豆、西兰花。该研究的目的是对年轻人饮食中叶黄素和玉米黄质的摄入量水平及来源进行回顾性评估,并研究饮食中的叶黄素和玉米黄质对黄斑密度的影响。使用一份专门设计的问卷来量化饮食中叶黄素和玉米黄质的含量,反映这些类胡萝卜素主要来源在调查前一天的食用量。采用一种非侵入性非接触式视网膜光学相干断层扫描方法来测定黄斑密度。该研究纳入了96名年龄在21 - 27岁的谢马什克大学学生。研究发现,只有6.25%的受访者每日叶黄素和玉米黄质摄入量达到或超过6毫克,8.33%的受访者摄入量为4.6 - 5.9毫克,8.33%的受访者摄入量为3.0 - 4.5毫克,18.75%的受访者摄入量为1.5 - 2.9毫克,45.83%的受访者摄入量小于1.4毫克。12.5%的受访者饮食中不包含叶黄素和玉米黄质的来源。饮食中叶黄素和玉米黄质较常见的来源是鸡蛋和新鲜番茄。大多数受检者的视网膜密度指数符合年龄标准。在8.3%的受调查者中,视网膜厚度降低,4.2%的受调查者视网膜厚度高于标准。研究揭示了男性和女性在中心子区域厚度上存在显著差异。食物来源的叶黄素和玉米黄质水平与视网膜厚度指标之间没有相关性。