猫麻疹病毒感染与猫肾组织特定病理变化的关联。

Association of feline morbillivirus infection with defined pathological changes in cat kidney tissues.

机构信息

Laboratory of Veterinary Microbiology, Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Tokyo, 183-8509, Japan; The United Graduate School of Veterinary Science, Gifu University, 1-1, Yanagido, Gifu, 501-1193, Japan; Department of Pre-Clinic and Applied Animal Science, Faculty of Veterinary Science, Mahidol University, Nakhon Pathom, 731170, Thailand.

Laboratory of Toxicology, Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Tokyo, 183-8509, Japan.

出版信息

Vet Microbiol. 2019 Jan;228:12-19. doi: 10.1016/j.vetmic.2018.11.005. Epub 2018 Nov 15.

DOI:10.1016/j.vetmic.2018.11.005

PMID:30593357

Abstract

Feline morbillivirus (FeMV) is an emerging member of morbillivirus discovered in 2012. Although association of FeMV infection with kidney diseases in cats has been suggested, the pathogenicity of the virus has not been clear to date. To study the association between FeMV infection and pathological changes in kidney tissues of infected cats, we performed immunohistochemistry and immunofluorescent assays to detect FeMV antigens and analyzed the effect of FeMV infection on the pathological changes in the kidney tissues. In 38 kidney tissue samples from cats, some tissue injury scores were significantly higher when the FeMV antigens were detected, especially those for the tubular tissues in which the FeMV antigens were mostly localized. Pathological changes associated with the FeMV antigens included the ones typically found in chronic kidney diseases, such as interstitial cell infiltration, glomerulosclerosis, tubular atrophy and fibrosis. We also detected some feline IgG localizations in glomerular tissues, though co-localization or significant association with the FeMV antigens were not found. Our study confirms the association of FeMV infection with some kidney tissue injuries and provides additional information about roles of FeMV infection in chronic kidney diseases.

摘要

猫传染性麻疹病毒（FeMV）是 2012 年发现的麻疹病毒的一个新兴成员。尽管已经提出了 FeMV 感染与猫肾脏疾病之间的关联，但该病毒的致病性迄今尚不清楚。为了研究 FeMV 感染与感染猫肾脏组织病理变化之间的关系，我们进行了免疫组织化学和免疫荧光检测，以检测 FeMV 抗原，并分析 FeMV 感染对肾脏组织病理变化的影响。在 38 份猫的肾脏组织样本中，当检测到 FeMV 抗原时，一些组织损伤评分明显升高，尤其是在 FeMV 抗原主要定位于的管状组织中。与 FeMV 抗原相关的病理变化包括慢性肾脏病中常见的变化，如间质细胞浸润、肾小球硬化、管状萎缩和纤维化。我们还在肾小球组织中检测到一些猫 IgG 的定位，尽管未发现与 FeMV 抗原的共定位或显著关联。本研究证实了 FeMV 感染与一些肾脏组织损伤之间的关联，并提供了关于 FeMV 感染在慢性肾脏病中的作用的更多信息。