循环内皮素的升压作用受到其在肺循环中被清除以及前列环素和内皮源性舒张因子释放的限制。
Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium-derived relaxing factor.
作者信息
de Nucci G, Thomas R, D'Orleans-Juste P, Antunes E, Walder C, Warner T D, Vane J R
机构信息
William Harvey Research Institute, St Bartholomew's Hospital Medical College, London, United Kingdom.
出版信息
Proc Natl Acad Sci U S A. 1988 Dec;85(24):9797-800. doi: 10.1073/pnas.85.24.9797.
Abstract
Endothelin releases prostacyclin and thromboxane A2 from guinea pig or rat isolated lungs and endothelium-derived relaxing factor in the perfused mesentery of the rat. Endothelin is also substantially removed by the pulmonary circulation of the rat in vitro and in vivo and by guinea pig lungs in vitro. In the rat, the effects of endothelin on the blood pressure vary from pressor (in pithed rats) to purely depressor in anesthetized rats where the resting blood pressure is high. It therefore has the characteristics of a local pressor hormone, rather than a circulating one.
摘要
内皮素可从豚鼠或大鼠离体肺中释放前列环素和血栓素A2，并能在大鼠灌注肠系膜中释放内皮源性舒张因子。在体外和体内，内皮素也可被大鼠的肺循环以及豚鼠的离体肺显著清除。在大鼠中，内皮素对血压的影响因动物状态而异，在脊髓横断大鼠中为升压作用，而在静息血压较高的麻醉大鼠中则表现为单纯的降压作用。因此，它具有局部升压激素的特征，而非循环激素。
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Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium-derived relaxing factor.循环内皮素的升压作用受到其在肺循环中被清除以及前列环素和内皮源性舒张因子释放的限制。
Proc Natl Acad Sci U S A. 1988 Dec;85(24):9797-800. doi: 10.1073/pnas.85.24.9797.
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